Journal of Endocrinology and Reproduction

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Serum Dihydrotestosterone is a Major Determinant of Bone Mineral Density in Men


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1 Department of Endocrinology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai - 600 113, India
     

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In the present investigation, 100 osteoporotic men with 100 age-matched normal were studied for serum sex steroids, parathyroid hormone (PTH), thyroid hormone (T3), cytokines and bone turnover markers. Serum dihydrotestosterone (DHT) was significantly decreased in osteoporotic men compared with normal. In osteoporotic men, there was a significant increase in serum interleukin (IL)-lalpha. A marked increase in bone formation marker, serum osteocalcin (OCN) and bone resorption marker, serum tartrate-resistant acid phosphatase (TRAP) reflects high bone turnover in osteoporotic men. In conclusion, the present findings point out an important role of DHT in maintaining BMD in men. A strong positive correlation of serum DHT with BMD offers new perspectives in understanding the role of non-aromatizable androgen in the regulation of bone metabolism in men.

Keywords

BMD, Cytokines, DHT.
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  • Serum Dihydrotestosterone is a Major Determinant of Bone Mineral Density in Men

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Authors

R. llangovan
Department of Endocrinology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai - 600 113, India
M. Balaganesh
Department of Endocrinology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai - 600 113, India
S. Sittadjody
Department of Endocrinology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai - 600 113, India
R. Sivakumar
Department of Endocrinology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai - 600 113, India
M. Sridhar
Department of Endocrinology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai - 600 113, India
R. C. Vignesh
Department of Endocrinology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai - 600 113, India
B. Ravi Sankar
Department of Endocrinology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai - 600 113, India
J. Arunakaran
Department of Endocrinology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai - 600 113, India
K. Balasubramanian
Department of Endocrinology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai - 600 113, India
M. Michael Aruldhas
Department of Endocrinology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai - 600 113, India
N. Srinivasan
Department of Endocrinology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai - 600 113, India

Abstract


In the present investigation, 100 osteoporotic men with 100 age-matched normal were studied for serum sex steroids, parathyroid hormone (PTH), thyroid hormone (T3), cytokines and bone turnover markers. Serum dihydrotestosterone (DHT) was significantly decreased in osteoporotic men compared with normal. In osteoporotic men, there was a significant increase in serum interleukin (IL)-lalpha. A marked increase in bone formation marker, serum osteocalcin (OCN) and bone resorption marker, serum tartrate-resistant acid phosphatase (TRAP) reflects high bone turnover in osteoporotic men. In conclusion, the present findings point out an important role of DHT in maintaining BMD in men. A strong positive correlation of serum DHT with BMD offers new perspectives in understanding the role of non-aromatizable androgen in the regulation of bone metabolism in men.

Keywords


BMD, Cytokines, DHT.



DOI: https://doi.org/10.18519/jer%2F2006%2Fv10%2F100852