International Journal of Medical Sciences

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Green Tea:A Natural Source of Drug for Liver Cancer


Affiliations
1 Department of Bioinformatics, University Institute of Engineering and Technology, Chhatrapati Shahu Ji Maharaj University, Kanpur (U.P.), India
2 Department of Bioinformatics, University Institute of Engineering and Technology, Chhatrapati Shahu Ji Maharaj University, Kanpur (U.P.), India
     

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Green tea (Camellia sinensis) has anticancer activity in animal. The HBx protein of Hepatitis B virus activate AP-1 protein and it causes the down regulation of PTEN and p53 which are tumor suppressor genes, leads to the tumor formation in liver. The interactions between HBx and AP-1 have been targeted by docking of natural compounds. EGCG obtained from green tea shows highest affinity for AP-1 protein among all natural compounds. Affinity of EGCG with AP-1 protein may be used to design drug for liver cancer.

Keywords

Liver Cancer, HBV, Activator Protein-1, Natural Compounds, EGCG, Docking.
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  • Green Tea:A Natural Source of Drug for Liver Cancer

Abstract Views: 195  |  PDF Views: 0

Authors

Rajesh Kumar Pathak
Department of Bioinformatics, University Institute of Engineering and Technology, Chhatrapati Shahu Ji Maharaj University, Kanpur (U.P.), India
Mamta Sagar
Department of Bioinformatics, University Institute of Engineering and Technology, Chhatrapati Shahu Ji Maharaj University, Kanpur (U.P.), India

Abstract


Green tea (Camellia sinensis) has anticancer activity in animal. The HBx protein of Hepatitis B virus activate AP-1 protein and it causes the down regulation of PTEN and p53 which are tumor suppressor genes, leads to the tumor formation in liver. The interactions between HBx and AP-1 have been targeted by docking of natural compounds. EGCG obtained from green tea shows highest affinity for AP-1 protein among all natural compounds. Affinity of EGCG with AP-1 protein may be used to design drug for liver cancer.

Keywords


Liver Cancer, HBV, Activator Protein-1, Natural Compounds, EGCG, Docking.