An Unusual Presentation of a Case of Primary Plasma Cell Leukaemia in a Psychotic Patient with Associated Tuberculosis

Plasma cell leukaemia (PCL) is a rare disorder that can develop spontaneously (primary) or evolve in patients with multiple myeloma (secondary). Histogenetically, plasma cell leukaemia is derived from terminally differentiated B cells. It is diagnosed by the presence of absolute plasma cell count > 2000/ cumm or > 20% circulating plasma cells in blood. We report a rare case of primary plasma cell leukaemia in a patient of bipolar affective disorder presenting with weakness of lower limbs, fatigability, generalized myalgia and mood changes. She was a known case of pulmonary tuberculosis. There was no previous history of multiple myeloma. Clinical spectrum, cytomorphological features and prognosis of PCL are discussed.