The Indian Practitioner

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Organophosphorus Poisoning Complicated by Acute Myocardial Infarction-A Case Report


Affiliations
1 J.L.N. Medical College, Ajmer, India
     

   Subscribe/Renew Journal


Acute organophosphate (OP) poisoning represents a major health problem in developing countries where OP compounds are widely and easily available as pesticide. Toxicity due to these agents can affect many organs including lungs, brain and heart. The possible mechanisms for myocardial injury include sympathetic/parasympathetic overactivity, hypoxemia, acidosis, dyselectrolemia, and direct cardio toxicity. Cardiac manifestations consist of electrocardiographic ST-T segment changes, AV conduction disturbances and QT prolongation, leading to torsades de pointes and sudden cardiac death. Acute coronary syndrome as a complication of OP poisoning has been reported rarely. We report herein a fatal case of OP poisoning complicated by acute myocardial infarction.

Keywords

Organophosphorus Compound, Cardiac Toxicity, Myocardial Infarction.
Subscription Login to verify subscription
User
Notifications
Font Size


  • International Programme on Chemical Safety, World Health Organization (WHO). Epidemiology of pesticide poisoning: harmonized collection of data on human pesticide exposure in selected countries. Geneva, Switzerland: WHO Press; 2004.

  • Linden CH, Burns MJ, Mycyk MB. Poisoning, drug overdose and envenomation. In: Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, et al., editors. Harrison’s Principles of Internal Medicine. 17th ed. New York: McGraw-Hill; 2008. p.2741-8.

  • Yamashita, M., M. Yamashita, J. Tanaka and Y. Ando, 1997. Human mortality in organophosphate poisonings. Vet. Hum. Toxicol., 39: 84-85

  • Karki P, Ansari JA, Bhandary S, Koirala S. Cardiac and electrocardiographical manifestations of acute organophosphate poisoning. Singapore Med J 2004;45:385-9

  • Kidiyoor Y, Nayak VC, Devi V, Bakkannavar SM, Kumar GP, Menezes RG. A rare case of myocardial infarction due to parathion poisoning. J Forensic Leg Med 2009;16:472-4.

  • Madhu Pankaj, Kavita Krishna. Acute Organophosphorus Poisoning Complicated by Acute Coronary Syndrome JAPI 2014;62;62-63

  • Ludomirsky A, Klein HO, Sarelli P, Becker B, Hoffman S, Taitelman U, Q-T prolongation and polymorphous (torsade de pointes) ventricular arrhythmias associated with Organophosphorus insecticide poisoning. Am J Cardiol 1982;49:1654-8.

  • Yasue H, Touyama M, Shimamoto M, Kato H, Tanaka S. Role-of autonomic nervous system in the pathogenesis of Prinzmetal’s variant form of angina. Circulation1974;50:534-9.

  • Karasu-Minareci E, Gunay N, Minareci K, Sadan G, Ozbey G. What may be happen after an organophosphate exposure: Acute myocardial infarction? J Forensic Leg Med 2012;19:94-6.


Abstract Views: 205

PDF Views: 1




  • Organophosphorus Poisoning Complicated by Acute Myocardial Infarction-A Case Report

Abstract Views: 205  |  PDF Views: 1

Authors

M. Maheshwari
J.L.N. Medical College, Ajmer, India
V. Sharma
J.L.N. Medical College, Ajmer, India

Abstract


Acute organophosphate (OP) poisoning represents a major health problem in developing countries where OP compounds are widely and easily available as pesticide. Toxicity due to these agents can affect many organs including lungs, brain and heart. The possible mechanisms for myocardial injury include sympathetic/parasympathetic overactivity, hypoxemia, acidosis, dyselectrolemia, and direct cardio toxicity. Cardiac manifestations consist of electrocardiographic ST-T segment changes, AV conduction disturbances and QT prolongation, leading to torsades de pointes and sudden cardiac death. Acute coronary syndrome as a complication of OP poisoning has been reported rarely. We report herein a fatal case of OP poisoning complicated by acute myocardial infarction.

Keywords


Organophosphorus Compound, Cardiac Toxicity, Myocardial Infarction.

References