Cardiodepressant Activity of Newer Dihydropyrimidine Derivative in Comparison to Nifedipine on Perfused Rabbits Heart

Background: Substituted dihydropyridine calcium channel blockers are used in the treatment of cardiovascular diseases. Dihydropyridines are considered as analogue of dihydropyrimidines.

Objectives: In present study newly synthesized test compound 5- Acyl-6-methyl-4(2',3'-methylenedioxy) phenyl - 2 - S - ethyl - 1, 4- dihydropyrimidine, a dihydropyrimidine derivative was investigated with an aim to get valuable substitute for the well known dihydropyridine, Nifedipine.

Material & Methods: The Calcium Channel blocking actiuity of test compound was studied on Rabbit's Heart and its effects were compared with Nifedipine used as control.

Results: Test compound has dose-dependent negative chronotropic and negative inotropic effect on Rabbit's heart but these effects appeared at doses higher than those of Nifedipine. Test compound had no significant change in coronary flow however Nifedipine show significant increase in coronary flow at lower doses.

Conclusion: Test compound appears to be less potent myocardial depressant compared to Nifedipine. Test compound produced calcium channel blocking activity which was dose related and in order to ascertain the status of this compound as a drug, further studies are needed not only in other animals and tissue models but also in various pathophysiological models.