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Comparative Evaluation of Metoprolol and Telmisartan in Hypertensive Patients


Affiliations
1 Pharmacology Pacific Medical College and hospital Udaipur, Rajasthan, India
2 Pharmacology Dr Harvansh Singh Judge Institute of Dental Sciences and Hospital Chandigarh, India
3 Pharmacology, Maharishi Markandeshwar Institute of Medical Sciences & Research Mullana, Ambala, India
4 Medicine, Maharishi Markandeshwar Institute of Medical Sciences & Research Mullana, Ambala, India
 

Background: Epidemiological studies and clinical trials have shown that meticulous control of blood pressure is required in patients with hypertension to ensure decreased cardiovascular morbidity and mortality.

Objective: To compare the effect of Metoprolol and Telmisartan on blood pressure reduction and heart rate in patients of Stage I Hypertension.

Material and Methods: This was a prospective, randomized, open, parallel study conducted at the outpatient department of Medicine. Patients of either sex with Grade I Hypertension according to JNC VII, aged between 18-60 years were enrolled and followed up every 2 weeks from baseline till 12 weeks. Patients were randomly divided into two groups to receive tablet Metoprolol 50 mg (Group A, n=30) and Telmisartan 40 mg (Group B, n=30) once a day. Response to study treatments was evaluated in terms of decrease in Blood pressure and heart rate. Results were analysed using Student's 't' test.

Results: Baseline characters of both the groups were well balanced. Systolic Blood Pressure was reduced by 7.5 % from Metoprolol and 12.9% by Telmisartan and Diastolic Blood Pressure was reduced by 8.2% in group A and 13.6% in group B. Both the drugs leads to significant reductions (i.e. P<0.05) in systolic as wel as diastolic BP. Heart rate reduction was significant and was observed to be more with the Metoprolol group i.e. 15.2% reduction as compared to 9.1% reduction with Telmisartan.

Conclusion: Telmisartan is a better choice than Metoprolol in Indian Population for treating Grade I hypertension as it leads to greater reduction in Blood Pressure and less effect on Heart rate.


Keywords

Grade I Hypertension, Metoprolol, Telmisartan, Systolic Blood Pressure, Diastolic Blood Pressure, Heart Rate.
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  • Comparative Evaluation of Metoprolol and Telmisartan in Hypertensive Patients

Abstract Views: 278  |  PDF Views: 137

Authors

Amrit Agarwal
Pharmacology Pacific Medical College and hospital Udaipur, Rajasthan, India
M. K. Chhabra
Pharmacology Dr Harvansh Singh Judge Institute of Dental Sciences and Hospital Chandigarh, India
Rani Walia
Pharmacology, Maharishi Markandeshwar Institute of Medical Sciences & Research Mullana, Ambala, India
P. D. Gupta
Medicine, Maharishi Markandeshwar Institute of Medical Sciences & Research Mullana, Ambala, India

Abstract


Background: Epidemiological studies and clinical trials have shown that meticulous control of blood pressure is required in patients with hypertension to ensure decreased cardiovascular morbidity and mortality.

Objective: To compare the effect of Metoprolol and Telmisartan on blood pressure reduction and heart rate in patients of Stage I Hypertension.

Material and Methods: This was a prospective, randomized, open, parallel study conducted at the outpatient department of Medicine. Patients of either sex with Grade I Hypertension according to JNC VII, aged between 18-60 years were enrolled and followed up every 2 weeks from baseline till 12 weeks. Patients were randomly divided into two groups to receive tablet Metoprolol 50 mg (Group A, n=30) and Telmisartan 40 mg (Group B, n=30) once a day. Response to study treatments was evaluated in terms of decrease in Blood pressure and heart rate. Results were analysed using Student's 't' test.

Results: Baseline characters of both the groups were well balanced. Systolic Blood Pressure was reduced by 7.5 % from Metoprolol and 12.9% by Telmisartan and Diastolic Blood Pressure was reduced by 8.2% in group A and 13.6% in group B. Both the drugs leads to significant reductions (i.e. P<0.05) in systolic as wel as diastolic BP. Heart rate reduction was significant and was observed to be more with the Metoprolol group i.e. 15.2% reduction as compared to 9.1% reduction with Telmisartan.

Conclusion: Telmisartan is a better choice than Metoprolol in Indian Population for treating Grade I hypertension as it leads to greater reduction in Blood Pressure and less effect on Heart rate.


Keywords


Grade I Hypertension, Metoprolol, Telmisartan, Systolic Blood Pressure, Diastolic Blood Pressure, Heart Rate.

References





DOI: https://doi.org/10.18311/ijmds%2F2014%2F81266