International Journal of Medical and Dental Sciences

Open Access Open Access  Restricted Access Subscription Access

Comparison of Effect of Bipolar I Disorder on Neurocognitive Functions between Full Biological Siblings of Patients from Simplex and Multiplex Families


Affiliations
1 Department of Psychiatry, Punjab Institute of Medical Sciences, Jalandhar, Punjab − 144006, India
2 Department of Psychiatry, Clinical Psychologist, Institute of Medical Sciences, Jalandhar, Punjab − 144006, India
 

Background: Cognitive deficits seem to be more prevalent in relatives of patients with bipolar disorder type I compared to relatives of BD type II patients. Assessment of cognitive performance in siblings of bipolar disorder from simplex (only one known case of bipolar disorder in first degree relatives) and multiplex (more than one known case of bipolar disorder in first degree relatives) families may provide some light to investigate the biological vulnerability in bipolar disorder. There is limited data pertaining to studies on siblings of patients with bipolar disorder and especially on comparison of effect of Bipolar I Disorder on neurocognitive functions between full biological siblings of patients from simplex and multiplex Families. Materials and Methods: This is a prospective, teaching hospital based, single point non-invasive study of 29 unaffected full biological siblings of patients diagnosed (as per DSM-IV-TR) as bipolar disorder I (BD-I) from Simplex and Multiplex families. Results: The siblings belonging to the multiplex group performed poorly on most domains of the Wisconsin Card Sorting Test (WCST). Comparison of the performance of the siblings belonging to the multiplex sub-group to those of simplex sub-group on the various domains of the Continuous Performance Test (CPT) and Spatial Working Memory Test (SWMT) did not show statistically significant difference. Conclusions: The performance in WCST is significantly affected in siblings from multiplex families than in simplex ones.


Keywords

Bipolar Disorder Type 1, Cognitive Performance, Multiplex, Siblings, Simplex.
User
Notifications
Font Size


  • Sobczak S, Honig A, Riedel WJ. Acute Tryptophan Depletion in bipolar disorders; literature review and directives for further research. Acta. Neuropsychiatrica. 2000; 12:69-72. https://doi.org/10.1017/S0924270800035432. PMid: 26975255.

  • Zalla, 2004, Zalla T, Joyce C, Szoke A, et. al. Executive dysfunctions as potential markers of familial vulnerability to bipolar disorder and schizophrenia. Psychiatry Res. 2004; 121:207-217. https://doi.org/10.1016/S0165-1781(03) 00252-X.

  • Keri S, Kelemen O, Benedek G, Janka Z. Different trait markers for schizophrenia and bipolar disorder: A neurocognitive approach. Psychol. Med. 2001; 31:915922. https://doi.org/10.1017/S0033291701004068. PMid: 11459389.

  • Sobczak S, Riedel WJ, Booij L, Aan Het Rot M, Deutz NEP, Honig A. Cognition following Acute Tryptophan Depletion: Differences between first-degree relatives of bipolar disorder patients and matched healthy control volunteers. Psychol. Med. 2002; 32:503-515. https://doi.org/10.1017/S0033291702005342. PMid: 11989995.

  • Goldberg D, McDowell I, Newell C. General Health Questionnaire (GHQ), 12 item version, 20 item version, 30 item version, 60 item version [GHQ12, GHQ20, GHQ30, GHQ60]. Measuring Health: A Guide to Rating Scales and Questionnaires (2nd Ed.). New York: Oxford U Pr; 1972; 181:225-236.

  • Baum AE, McMahon FJ. A genome-wide association study implicates diacylglycerol kinase ETA (DGKH) and several other genes in the etiology of disorder, Molecular Psychiatry. 2007. https://doi.org/10.1038/sj.mp.4002012. PMid:17486107, PMCid: PMC2527618.

  • ==Zandi PP, Belmonte PL, Willour VL, Goes FS, Badner JA, Simpson SG, Gershon ES, McMahon FJ, DePaulo Jr JR, Potash JB. Bipolar Disorder Phenome Group; National Institute of Mental Health Genetics Initiative Bipolar Disorder Consortium; Association Study of Wnt. Signaling Pathway Genes in Bipolar Disorder. Arch. Gen. Psychiatry. 2008; 65(7):785-793. https://doi.org/10.1001/archpsyc.65.7.785. PMid: 18606951, PMCid: PMC3170992.

  • Antila M, Tuulio-Henriksson A, Kieseppa T, Eerola M, Partonen T, Lonnqvist J. Cognitive functioning in patients with familial bipolar I disorder and their unaffected relatives. Psychol. Med. 2006; 21:1-9. https://doi.org/10.1017/S0033291706009627. PMid: 17181912.

  • Ferrier IN, Chowdhury R, Thompson JM, Watson S, Young AH. Neurocognitive function in unaffected first-degree relatives of patients with bipolar disorder: A preliminary report. Bipolar Disord. 2004; 6(4):319-22. https://doi.org/10.1111/j.1399-5618.2004.00122.x. PMid: 15225150.

  • Szoke A, Schurhoff F, Golmard JL, Alter C, Roy I, Meary A, et al., Familial resemblance for executive functions in families of schizophrenic and bipolar patients. Psychiatry Res. 2006; 144(2-3):131-138. Epub 2006 Oct 2. https:// doi.org/10.1016/j.psychres.2005.11.013. PMid: 17011636, PMCid: PMC1933530.

  • Christensen MV, Kyvik KO, Kessing LV. Cognitive function in unaffected twins discordant for affective disorder. Psychol. Med. 2006; 36(8):1119-1129 https://doi.org/10.1017/S0033291706007896. PMid: 16734950.

  • Sobczak S, Riedel WJ, Booij L, Aan Het Rot M, Deutz NEP, Honig A. Cognition following Acute Tryptophan Depletion: differences between first-degree relatives of bipolar disorder patients and matched healthy control volunteers. Psychol. Med. 2002; 32:503-515. https://doi.org/10.1017/S0033291702005342. PMid: 11989995

  • Chowdhury R, Ferrier IN, Thompson JM. Cognitive dysfunction in bipolar disorder. Curr. Opin. Psychiatry. 2003; 16(1):7-12. https://doi.org/10.1097/00001504-200301 000-00003.

  • Zalla T, Joyce C, Szoke A, et al. Executive dysfunctions as potential markers of familial vulnerability to bipolar disorder and schizophrenia. Psychiatry Res. 2004; 121:207-217. https://doi.org/10.1016/S0165-1781(03)00252-X.

  • Keri S, Kelemen O, Benedek G, Janka Z. Different trait markers for schizophrenia and bipolar disorder: A neurocognitive approach. Psychol Med. 2001; 31:915-922. https://doi.org/10.1017/S0033291701004068. PMid: 11459389.


Abstract Views: 232

PDF Views: 110




  • Comparison of Effect of Bipolar I Disorder on Neurocognitive Functions between Full Biological Siblings of Patients from Simplex and Multiplex Families

Abstract Views: 232  |  PDF Views: 110

Authors

Himanshu Sareen
Department of Psychiatry, Punjab Institute of Medical Sciences, Jalandhar, Punjab − 144006, India
Nidhi Bhanot
Department of Psychiatry, Clinical Psychologist, Institute of Medical Sciences, Jalandhar, Punjab − 144006, India

Abstract


Background: Cognitive deficits seem to be more prevalent in relatives of patients with bipolar disorder type I compared to relatives of BD type II patients. Assessment of cognitive performance in siblings of bipolar disorder from simplex (only one known case of bipolar disorder in first degree relatives) and multiplex (more than one known case of bipolar disorder in first degree relatives) families may provide some light to investigate the biological vulnerability in bipolar disorder. There is limited data pertaining to studies on siblings of patients with bipolar disorder and especially on comparison of effect of Bipolar I Disorder on neurocognitive functions between full biological siblings of patients from simplex and multiplex Families. Materials and Methods: This is a prospective, teaching hospital based, single point non-invasive study of 29 unaffected full biological siblings of patients diagnosed (as per DSM-IV-TR) as bipolar disorder I (BD-I) from Simplex and Multiplex families. Results: The siblings belonging to the multiplex group performed poorly on most domains of the Wisconsin Card Sorting Test (WCST). Comparison of the performance of the siblings belonging to the multiplex sub-group to those of simplex sub-group on the various domains of the Continuous Performance Test (CPT) and Spatial Working Memory Test (SWMT) did not show statistically significant difference. Conclusions: The performance in WCST is significantly affected in siblings from multiplex families than in simplex ones.


Keywords


Bipolar Disorder Type 1, Cognitive Performance, Multiplex, Siblings, Simplex.

References





DOI: https://doi.org/10.18311/ijmds%2F2020%2F24771