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Epidermal Growth Factor Improves the Ultrastructure of Submandibular Salivary Glands of Streptozotocin Induced Diabetic Rats - A Qualitative Study


Affiliations
1 Department of Oral Biology, The British University in Egypt, Cairo, Egypt
2 School of Dentistry and Oral Health, Griffith University, Queensland - 4222, Australia
 

Diabetes has well known damaging effects on different tissues of the body including salivary glands. Epidermal Growth Factor (EGF) facilitates healing and repair through different mechanisms including the increase in the activation and proliferation of fibroblasts. The aim of this study was to investigate if the effect of EGF was enough to repair the damage caused by diabetes in streptozotocin induced diabetic rats. Sixty adult male albino rats were divided into three groups. A control group, a streptozotocin induced diabetic group, and EGF group that was subjected to a single daily EGF intraperitoneal injection for two months after induction of diabetes. Submandibular salivary glands were dissected and examined using transmission electron microscopy. The diabetic group showed severe signs of atrophy and damage affecting all glandular components. The EGF group showed marked improvement in all elements of the submandibular salivary glands. Conclusions: EGF restored the structural integrity of submandibular salivary glands in diabetic rats.

Keywords

Diabetes, Epidermal Growth Factor, Ubmandibular Salivary Gland, Ultrastructure
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  • Epidermal Growth Factor Improves the Ultrastructure of Submandibular Salivary Glands of Streptozotocin Induced Diabetic Rats - A Qualitative Study

Abstract Views: 271  |  PDF Views: 116

Authors

Mahmoud Al Ankily
Department of Oral Biology, The British University in Egypt, Cairo, Egypt
Mohamed Shamel
Department of Oral Biology, The British University in Egypt, Cairo, Egypt
Mahmoud M. Bakr
School of Dentistry and Oral Health, Griffith University, Queensland - 4222, Australia

Abstract


Diabetes has well known damaging effects on different tissues of the body including salivary glands. Epidermal Growth Factor (EGF) facilitates healing and repair through different mechanisms including the increase in the activation and proliferation of fibroblasts. The aim of this study was to investigate if the effect of EGF was enough to repair the damage caused by diabetes in streptozotocin induced diabetic rats. Sixty adult male albino rats were divided into three groups. A control group, a streptozotocin induced diabetic group, and EGF group that was subjected to a single daily EGF intraperitoneal injection for two months after induction of diabetes. Submandibular salivary glands were dissected and examined using transmission electron microscopy. The diabetic group showed severe signs of atrophy and damage affecting all glandular components. The EGF group showed marked improvement in all elements of the submandibular salivary glands. Conclusions: EGF restored the structural integrity of submandibular salivary glands in diabetic rats.

Keywords


Diabetes, Epidermal Growth Factor, Ubmandibular Salivary Gland, Ultrastructure

References





DOI: https://doi.org/10.18311/ijmds%2F2020%2F24452