International Journal of Medical and Dental Sciences

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Relation between Obesity and Osteoporosis in Women


Affiliations
1 Department of Physiology, Punjab Institute of Medical Sciences, Jalandhar, Punjab, India
2 Department of Orthopedics, Punjab Institute of Medical Sciences, Jalandhar, Punjab, India
 

Background: Osteoporosis is a multifactorial skeletal disease, whose mechanisms are not fully understood. It is more common in older people, especially in Post menopausal women. Body Mass Index (BMI) is often used to predict Bone Mineral Density (BMD). Obese women have always been considered protected against Osteoporosis and Osteoporotic fractures. Objectives: Several studies have challenged the widespread belief that obesity is protective against fracture. The aim of this study was to assess the effects of BMI on BMD in premenopausal and postmenopausal women.

Material and Methods: The study was conducted on 400 women divided into two age groups of 21-50 years (premenopausal) and 51 - 90 years (post menopausal). Subjects having history of diseases or drugs that might influence BMD were excluded from the study. Height (m) and weight (kg) were measured and BMI was calculated. Calcaneus bone was scanned for QUS to measure BMD. The diagnosis of Osteoporosis and Osteopenia were done according to WHO T- score criteria. The whole data was collected and statistically analyzed using Correlation Coefficients and Pearson's Chi Square test.

Results: Pearson's correlation analysis showed a positive correlation between age and BMI but no significant correlation between BMI and BMD.

Conclusions: The results showed that there was no statistically significant relationship between BMI and BMD (p value > 0.05). According to our results, there is no protective role of Obesity in the development of Osteoporosis. There must be more detailed study in molecular and cellular level to explain the role and influence of obesity on BMD in women.


Keywords

Obesity, BMI, Osteoporosis, BMD, Women.
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  • Robert Lindsay R, Cosman F. Osteoporosis. In: Kasper DL, Fauci AS, editors. Harrison’s principles of Internal Medicine. 16th ed. New York USA: Mc Graw Hill; 2008: p.2268-78.

  • Caffarelli C, Alessi C, Nuti R, Gonnelli S. Clin Interv Aging. 2014 Sep 24;9:1629-36.

  • Kanis JA, Delmas P, Burckhardt P, Cooper C, Torgerson D. Guidelines for diagnosis and management of osteoporosis. Osteoporosis Int. 1997;7:390-406.

  • BMI classification according to WHO. Available at: http://apps.who.int/bmi/index.jsp?intro Page =intro_3.html.

  • Bone Mass Measurement: What the Numbers Mean. Available at: http://www.niams.nih.gov /health_info/bone/bone_he. Accessed February 19th 2016.

  • Robbins J, Schott AM, Azari R, Kronmal R. Body mass index is not a good predictor of bone density: results from WHI, CHS, and EPIDOS. Journal of Clinical Densitometry 2006;9(3):329-34.

  • Oommen A, AlZahrani IH, Shoro AS, Alruwaili J, Aboalseel B. Relationship between body mass index and Bone mineral density in Saudi women above 40 years with Vitamin D deficiency. Science Journal of Public Health2014;2(6):601-4.

  • Saravi FD, Sayegh F. Bone mineral density and body composition of adult premenopausal women with three levels of physical activity. J Osteoporos 2013;2013:953271.

  • Lloyd JT, Alley DE, Hawkes WG, Hochberg MC, Waldstein SR, Orwig DL. Body mass index is positively associated with bone mineral density in US older adults. Arch Osteoporos 2014 Dec;9(1):175.

  • Fawzy T, Muttappallymyalil J, Sreedharan J, Ahmed A, Alshamsi SS, Ali MS, et al. Journal of Osteoporosis 2011; Article ID 876309.

  • Greco EA, Formari R, Rossi F, Santiemma V, Prossomariti G, Annoscia C, et al. Is obesity protective for osteoporosis? Evaluation of bone mineral density in individuals with high body mass index. Int J Clin Pract 2010 May;64(6):817-20.


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  • Relation between Obesity and Osteoporosis in Women

Abstract Views: 252  |  PDF Views: 162

Authors

Shiveta Bansal
Department of Physiology, Punjab Institute of Medical Sciences, Jalandhar, Punjab, India
Aman Bansal
Department of Orthopedics, Punjab Institute of Medical Sciences, Jalandhar, Punjab, India

Abstract


Background: Osteoporosis is a multifactorial skeletal disease, whose mechanisms are not fully understood. It is more common in older people, especially in Post menopausal women. Body Mass Index (BMI) is often used to predict Bone Mineral Density (BMD). Obese women have always been considered protected against Osteoporosis and Osteoporotic fractures. Objectives: Several studies have challenged the widespread belief that obesity is protective against fracture. The aim of this study was to assess the effects of BMI on BMD in premenopausal and postmenopausal women.

Material and Methods: The study was conducted on 400 women divided into two age groups of 21-50 years (premenopausal) and 51 - 90 years (post menopausal). Subjects having history of diseases or drugs that might influence BMD were excluded from the study. Height (m) and weight (kg) were measured and BMI was calculated. Calcaneus bone was scanned for QUS to measure BMD. The diagnosis of Osteoporosis and Osteopenia were done according to WHO T- score criteria. The whole data was collected and statistically analyzed using Correlation Coefficients and Pearson's Chi Square test.

Results: Pearson's correlation analysis showed a positive correlation between age and BMI but no significant correlation between BMI and BMD.

Conclusions: The results showed that there was no statistically significant relationship between BMI and BMD (p value > 0.05). According to our results, there is no protective role of Obesity in the development of Osteoporosis. There must be more detailed study in molecular and cellular level to explain the role and influence of obesity on BMD in women.


Keywords


Obesity, BMI, Osteoporosis, BMD, Women.

References





DOI: https://doi.org/10.18311/ijmds%2F2017%2F125559