Current Science

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We evaluate the relative quantification of mRNA expression levels of the gene encoding an enzyme that catal­yses initial step in glycosylation of dolichol-linked oligosaccharide such as dolichyl-phosphate N-acetyl­glucosaminephosphotransferase 1 (DPAGT1). Further­more, beta-1,4-mannosyl-glycoprotein 4-beta-N-acetyl­glucosaminyltransferase (MGAT3) and alpha-1,6-man­nosylglycoprotein 6-beta-N-acetylglucosaminyltransferase (MGAT5) mediated N-glycosylation, selected a2, 3, a2, 6 sialyltransferases families and sialidase by using the Real-Time Quantitative Reverse Transcription PCR (qRT-PCR). Thirty human oral cancer tissue samples and twelve control samples were examined. Results indi­cated significant upregulation of ST6 N-acetylgalactos­aminide alpha-2,6-sialyltransferase 1 (ST6GALNAC1) in oral cancer compared to controls. Additionally, the expressions of DPAGT1, MGAT3, MGAT5, ST3 beta-galactoside alpha-2,3-sialyltransferase 1 (ST3GAL1), ST6 beta-galactoside alpha-2,6-sialyltransferase 1 (ST6­GAL1), and ST6GALNAC1 were considerably higher in the tumour in tongue lesion compared to the buccal cavity. Hence, our experiment demonstrates significance of glycosyltransferases in the progression of oral cancer

Keywords

Aberrant Glycosylation, Invasion, Metastasis, Oral Cancer, Sialyltransferase
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