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In this note I discuss in some detail how the IISER initiative towards excellence in science originated and how was it pursued, which culminated in the sanctioning of IISERs. I will also discuss similar other initiatives, like NISER, CBS, IISc, CMI and ISI towards excellence in science. Finally, based on my experience in the last four and half years at IISER Pune, I will point out the strengths as well as shortcomings of the IISER programme.
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