Asian Journal of Research in Pharmaceutical Sciences

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Review on: Solubility Enhancement of Poorly Water Soluble Drugs


Affiliations
1 Department of Quality Assurance Technuiqe, Pravara Rural College of Pharmacy, Loni, 413736,, India
2 Department of Pharmaceutics, Pravara Rural College of Pharmacy, Loni, 413736,, India
     

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About 40% of newly discovered chemicals are lipophilic, and because of their poor solubility in water they are unable to reach the market due to their solubility in water. Solubility is one of the limitations of the oral medication regimen to obtain its required concentration in the circulatory system in order to respond scientifically. There are various techniques used to improve melting point such as, Solid dispersion, micronization, Salt formation, Inclusion complexation are some mostly use techniques Novel approaches such as nano-suspension, supercritical processing, and cryogenic technologies may improve the delivery of poorly soluble medications. One of the most challenging parts of formulation creation is drug solubility behavior.

Keywords

Solubility enhancement, Bioavailability, Solubility, Solubility enhancement techniques.
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  • Sheetal Z Godse1, Mohini S Patil1, Swapnil M Kothavade1, R. B. Saudagar2; Phytochemical and Pharmacological Profile of lanatacamara L.: An Overview; J. Adv. Pharm. Edu. & Res. 2013: 3(4): 403-414.

  • Pharmaceutical Composite of Poorly Water Soluble Drugs And Polymers. Int. Application published under the patent cooperation Treaty (PCT), WIPO.Int. Publication no. (WO2012/085197A1): 1-58.

  • Remington: The Science and Practice of Pharmacy, Vol.2, 21st Edition. Published by Wolter Kluwer Health (India):196,211-229, 2005.

  • Alton’s Pharmaceutics: The design and manufacturing of medicines, Churchill Livingstone Elsvier.3rd edition: 322-538.

  • Wahab A, Khan A, Khan G.M. Preparation And Evaluation Of Solid Dispersions Of Ibuprofen Using Glucosamine HCL As A Carrier. British Journal of Pharmaceutical Research, 2013;3(4): 722-733.

  • Sandip Kumar, Pritam Singh, Various techniques for solubility enhancement: An overview, The Pharma Innovation Journal 2016; 5(1): 23-28

  • Mankar S. D, Rachh P. R, Solubility enhancement of poor water soluble drugs by solid dispersion: a review, Journal of Drug Delivery and Therapeutics. 2018; 8(5):44-49

  • Reddy B., Karunakar A, Biopharmaceutics classification system: a regulatory approach, Dissolution Technologies 2011; 31-37.

  • Chaudhary A, Nagaich U, Gulati N, Sharma V, Khosa R, Enhancement of Solubilization and Bioavailability Of Poorly Soluble Drugs By Physical And Chemical Modifications: A recent review, Journal of Advanced Pharmacy Education and Research 2012; 2:1: 32-67.

  • Arunachalam A, Karthikeyan M, Kishore K, Pottabathula H.P, Sethuraman S, Hutosh kumar S.A. Solid Dispersions. Current Pharma Research, 2010,1(1).

  • Kapadiya N, Indrjeet S, Mehta K, Karwani G, Shrubo J.S. Hydrotropy: A Promising Tool for Solubility Enhancement. Int. J Drug Discovery and Resarch, 2011;3(2):26-33.

  • Jain P, Goel A, Sharma S, Parmar M. Solubility enhancement techniques with special emphasis on hydrotrophy. International Journal of Pharma Professional’s Research, 2010.

  • S. V. Kadam, D. M. Shinkar, R. B. Saudagar, Review on Solubility Enhancement Techniques, International Journal of Pharmacy and Biological Sciences (e-ISSN: 2230-7605)

  • Sharma D, Soni M, Kumar S, Gupta G.D, Solubility Enhancement -Eminent Role in Poorly Soluble Drugs. Research Journal of Pharmacy and Technology, 2: 220-224, (2009)

  • Vasconcelos T. F, Sarmento B, Costa P, Solid dispersion as strategy to improve oral bioavailability of poor water soluble drugs. Drug Discovery Today, 12: 1068-1075, (2007)

  • Kamalakkannan V, Puratchikody A, Masilamani K, Senthilnathan B, Solubility enhancement of poorly soluble drugs by solid dispersion technique–A review. Journal of Pharmacy Research, 3: 2314-2321, (2010)

  • Subramaniam B, Rajewski R. A, Snavely K, Pharmaceutical processing with supercritical carbon dioxide. Journal of Pharmaceutical Science, 86: 885-890, (1997)

  • Phillips E.M, Stella V.J, Rapid expansion from supercritical solutions: application to pharmaceutical processes. International Journal of Pharmaceutics, 94: 1-10, (1993)

  • Soni S, Patel T, Thakar B, Dr. Pandya V, Dr. Bharadia P, Nanosuspension: An Approach to Enhance Solubility of Drugs.


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  • Review on: Solubility Enhancement of Poorly Water Soluble Drugs

Abstract Views: 134  |  PDF Views: 0

Authors

M H Markad
Department of Quality Assurance Technuiqe, Pravara Rural College of Pharmacy, Loni, 413736,, India
S D Mankar
Department of Pharmaceutics, Pravara Rural College of Pharmacy, Loni, 413736,, India

Abstract


About 40% of newly discovered chemicals are lipophilic, and because of their poor solubility in water they are unable to reach the market due to their solubility in water. Solubility is one of the limitations of the oral medication regimen to obtain its required concentration in the circulatory system in order to respond scientifically. There are various techniques used to improve melting point such as, Solid dispersion, micronization, Salt formation, Inclusion complexation are some mostly use techniques Novel approaches such as nano-suspension, supercritical processing, and cryogenic technologies may improve the delivery of poorly soluble medications. One of the most challenging parts of formulation creation is drug solubility behavior.

Keywords


Solubility enhancement, Bioavailability, Solubility, Solubility enhancement techniques.

References