Asian Journal of Research in Pharmaceutical Sciences

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Formulation and Characterization of Mucoadhesive Microspheres of Oxazolidines Class Drug for the Treatment of Loosen Enteritis


Affiliations
1 Divya Laboratories, Department of Research and Development, Amravati-444604, India
2 Divya Laboratories, Department of Research and Development, Amravati-444604., India
     

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This study aimed to developed novel fast disintegrating sustained release pellets containing tablet by using Fluidized Bed processor. Verapamil HCl used as a model drug for the formulation. Fluidized bed processor was used for coating of drug and polymer on the sugar spheres. To overcome the problem of swallowing for paediatric, geriatric, psychiatric, bedridden patients, uncooperative patients or for active patients who are busy and travelling and may not access to we aim to formulate the fast-disintegrating tablet. The superdisintigrant are commonly use like cross povidone, sodium starch glycolate which disintegrate tablet rapidly. It is assumed that, after the disintegration of tablets, pellets within tablets which are reside in GIT for several hours and gradually released a drug in controlled way. Eudragit RS 30D and ethyl cellulose were used as a sustained release polymer. Coating of spheres with sustained release film is achieved by bottom spray processor of FBP. Proper pellets coating film thickness, and concentration of polymers’, ensure obtaining desirable VH release profile for extended period of time, was defined. X composition of tablet with pellets were examined in order to obtained formulation, from which VH release would mostly appropriate pellets before compressing. Compression of pellets into tablet, being a modern technological process than enclosing them into hard gelatine capsule. The optimized batch evaluated by studied the effect of compression force, tablet hardness and friability and drug release from the pellets by sustained release manner.

Keywords

Mucoadhesive Microspheres, Oxizolidines, Loosen Entritis, Chitosan, ANOVA.
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  • Gray JA. Gastro-enteritis Associated with Proteus Vulgaris. British Medical Journal. 1937 May 1;1(3982):916.

  • Ali BH. Pharmacological, therapeutic and toxicological properties of furazolidone: some recent research. Veterinary Research Communications. 1999 Oct;23(6):343-60.

  • Craft JC, Murphy T, Nelson JD. Furazolidone and quinacrine: comparative study of therapy for giardiasis in children. American Journal of Diseases of Children. 1981 Feb 1;135(2):164-6.

  • Malviya VR, Pande SD, Bobade NN. Preparation and Evaluation of Sustained Release Beads of Zolmitriptan Hydrochloride. Research Journal of Pharmacy and Technology. 2019; 12(12): 5972-6.

  • Deshmukh VN, Jadhav JK, Masirkar VJ, Sakarkar DM. Formulation, optimization and evaluation of controlled release alginate microspheres using synergy gum blends. Research Journal of Pharmacy and Technology. 2009; 2(2): 324-7.

  • Malviya VR, Pande SD. Road CKN. Preparation ad Evaluation of Zolmitriptan Hydrochloride Lozenge. J Pharma Res. 2019; 8(8): 624-9.

  • Shankar NB, Kumar NU, Balakrishna PK, Kumar RP. Preparation and in vitro evaluation of lamivudine entrapped MOI microspheres for oral administration. Research Journal of Pharmacy and Technology. 2008; 1(4):437-40.

  • Malviya V, Manekar S. Design, Development and Evaluation of Aceclofenac and Curcumin Agglomerates by Crystallo Co-Agglomeration Technique. Research Journal of Pharmacy and Technology. 2021 Mar 18;14(3):1535-41.

  • Ghosh A, Nayak UK, Rout P, Nag T, Roy P. Preparation, Evaluation and in vitro-in vivo Correlation (IVIVC) study of Lamivudine Loaded Microspheres. Research Journal of Pharmacy and Technology. 2008;1(4):353-6.

  • Malviya V. Preparation and Evaluation of Emulsomes as a Drug Delivery System for Bifonazole. Indian Journal of Pharmaceutical Education and Research. 2021;55(1): 86-94.

  • Venkateswaramurthy N, Sambathkumar R, Vijayabaskaran M, Perumal P. Preparation and Evaluation of Mucoadhesive Microspheres Containing Heparin for Antiulcer Therapy. Research Journal of Pharmacy and Technology. 2011; 4(2): 268-70.

  • Chakraborty S, Jana S, Gandhi A, Sen KK, Zhiang W, Kokare C. Gellan gum microspheres containing a novel α-amylase from marine Nocardiopsis sp. strain B2 for immobilization. International Journal of Biological Macromolecules. 2014; 70: 292-9.

  • Hajare AA, Shetty YT. Formulation, characterization and in-vitro evaluation of floating microspheres of diltiazem hydrochloride by ionotropic gelation technique. Research Journal of Pharmacy and Technology. 2008;1(1):52-6.

  • Bayomi MA, Al-Suwayeh SA, El-Helw AM, Mesnad AF. Preparation of casein–chitosan microspheres containing diltiazem hydrochloride by an aqueous coacervation technique. Pharmaceutica Acta Helvetiae. 1998; 73(4): 187-92.

  • Shaji J, Shinde A. Formulation and evaluation of floating pulsatile microspheres of aceclofenac for rheumatoid arthritis. Research Journal of Pharmacy and Technology. 2011; 4(12): 1877-81.

  • Nighute AB, Bhise SB. Preparation and Evaluation of Microspheres of Rifabutin using Eudragit Polymers. Research Journal of Pharmacy and Technology. 2009; 2(4): 680-4.

  • Kumar RP, Amitava G, Kumar NU, Shankar NB. Formulation Design, Preparation of Losartan Potassium Microspheres by W/O Emulsion Solvent Evaporation Method and It's In Vitro Characterization. Research Journal of Pharmacy and Technology. 2009; 2(3): 513-6.

  • Kumar RP, Amitava G, Kumar NU, Shankar NB. Formulation Design, Preparation of Losartan Potassium Microspheres by W/O Emulsion Solvent Evaporation Method and It's In Vitro Characterization. Research Journal of Pharmacy and Technology. 2009; 2(3): 513-6.


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  • Formulation and Characterization of Mucoadhesive Microspheres of Oxazolidines Class Drug for the Treatment of Loosen Enteritis

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Authors

Rahul Rajge
Divya Laboratories, Department of Research and Development, Amravati-444604, India
Saad Khan
Divya Laboratories, Department of Research and Development, Amravati-444604., India

Abstract


This study aimed to developed novel fast disintegrating sustained release pellets containing tablet by using Fluidized Bed processor. Verapamil HCl used as a model drug for the formulation. Fluidized bed processor was used for coating of drug and polymer on the sugar spheres. To overcome the problem of swallowing for paediatric, geriatric, psychiatric, bedridden patients, uncooperative patients or for active patients who are busy and travelling and may not access to we aim to formulate the fast-disintegrating tablet. The superdisintigrant are commonly use like cross povidone, sodium starch glycolate which disintegrate tablet rapidly. It is assumed that, after the disintegration of tablets, pellets within tablets which are reside in GIT for several hours and gradually released a drug in controlled way. Eudragit RS 30D and ethyl cellulose were used as a sustained release polymer. Coating of spheres with sustained release film is achieved by bottom spray processor of FBP. Proper pellets coating film thickness, and concentration of polymers’, ensure obtaining desirable VH release profile for extended period of time, was defined. X composition of tablet with pellets were examined in order to obtained formulation, from which VH release would mostly appropriate pellets before compressing. Compression of pellets into tablet, being a modern technological process than enclosing them into hard gelatine capsule. The optimized batch evaluated by studied the effect of compression force, tablet hardness and friability and drug release from the pellets by sustained release manner.

Keywords


Mucoadhesive Microspheres, Oxizolidines, Loosen Entritis, Chitosan, ANOVA.

References