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Development and Validation of Simultaneous Equation UV-Spectrophotometric Method for the Estimation of Telmisartan and Amlodipine besylate in Combined Dosage Form


Affiliations
1 Department of Pharmaceutical Chemistry, IIMT College of Medical Sciences, Meerut-250001
2 HOD, Department of Pharmaceutical Chemistry, IIMT College of Medical Sciences, Meerut
     

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A simple, sensitive, precise and specific UV spectrophotometric method for simultaneous estimation of Telmisartan and Amlodipine besylate in combine dosage form has been developed. The wavelengths 238 nm and 295 nm were selected for estimation of Amlodipine besylate and Telmisartan respectively, where Methanol was used as solvent. Linearity were observed in the concentration range of 2-25 µg/ml (r2=0.9994) and 2-30 µg/ml (r2=0.9999) for Telmisartan and Amlodipine besylate respectively. These methods were validated according to ICH guidelines

Keywords

Telmisartan, Amlodipine Besylate, Simultaneous Equation Method
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  • Development and Validation of Simultaneous Equation UV-Spectrophotometric Method for the Estimation of Telmisartan and Amlodipine besylate in Combined Dosage Form

Abstract Views: 307  |  PDF Views: 1

Authors

Shishir Maheshwari
Department of Pharmaceutical Chemistry, IIMT College of Medical Sciences, Meerut-250001
Preeti Tiwari
HOD, Department of Pharmaceutical Chemistry, IIMT College of Medical Sciences, Meerut
Atul Srivastav
Department of Pharmaceutical Chemistry, IIMT College of Medical Sciences, Meerut-250001

Abstract


A simple, sensitive, precise and specific UV spectrophotometric method for simultaneous estimation of Telmisartan and Amlodipine besylate in combine dosage form has been developed. The wavelengths 238 nm and 295 nm were selected for estimation of Amlodipine besylate and Telmisartan respectively, where Methanol was used as solvent. Linearity were observed in the concentration range of 2-25 µg/ml (r2=0.9994) and 2-30 µg/ml (r2=0.9999) for Telmisartan and Amlodipine besylate respectively. These methods were validated according to ICH guidelines

Keywords


Telmisartan, Amlodipine Besylate, Simultaneous Equation Method

References