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Absorption Correction Method for Simultaneous Spectrophotometric Estimation of Flunarizine Dihydrochloride and Propranolol HCl in Combined Capsule Dosage Form
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A new, simple, sensitive, accurate and precise UV ‐ spectrophotometric absorption correction method for simultaneous estimation of flunarizine dihydrochloride and propranolol HCl in capsule dosage form has been developed and validated for accuracy, precision, ruggedness, linearity and range. The wavelengths selected for estimation of drugs were 253.2 nm for flunarizine dihydrochloride and 288.8 nm for propranolol HCl. Linearity for detector response for flunarizine dihydrochloride and propranolol HCl were 1-25 µg/ml and 4-100 μg/ml respectively. The method gives results for high accuracy and high recovery of 99.15±1.37 and 100.02±0.89 for flunarizine dihydrochloride and propranolol HCl respectively. % R.S.D. Values for marketed formulation analysis were found to be less than 2 which indicated good precision and reproducibility of the method.
Keywords
Flunarizine dihydrochloride, Propranolol HCl, Absorption correction method
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- British Pharmacopoeia, The Department of Health, published by The Stationery office on behalf of medicines and Healthcare products Regulatory Agency.2007;Vol. I: 890-891.
- Indian Pharmacopoeia, Government of India, Ministry of Health and Family Welfare, published by The Indian Pharmacopoeia commission Ghaziabad. 2010; Vol III: 1987-1988.
- Schmidt R and OestreichW. Flunarizine in Migraine Prophylaxis: The Clinical Experience, Journal of Cardiovascular Pharmacology, 1991:18, 21-26.
- Jain SK, Jain D, Tiwari M, Chaturvedi SC. Simultaneous spectrophotometric estimation of propranolol hydrochloride and hydrochlorthiazide in pharmaceutical formulation. Indian J Pharm Sci.2002; 64: 267- 270.
- Mohammad MAA. Spectrophotometric and Spectrofluorimetric determination of Cinnarizine and flunarizine Dihydrochloride in pure and dosage forms. Bull Fac Pharm, 2004; 42: 27-40.
- Jonczyk A, Nowakowska Z. Determination of hydrochlorothiazide, triamterene and propranolol hydrochloride by the spectrophotometric method and high performance liquid chromatography (HPLC). Acta Pol Pharm.200; 58:339-344.
- Wahbi AA, El-Walily AF, Hassan EM, Saliman FG, El-Gendi AJ. Liquid chromatographic determination of Flunarizine dihydrochloride in the presence of its degradation product. PharmBiomed Anal. 1995;13: 77-84.
- Kartinasari WF, Chufianty H, Indrayanto G. HPLC determination of Flunarizine dihydrochloride in Tablets and Its Validation. Journal of Liquid Chromatography and Related Technologies. 2003; 26: 1059-1067.
- Bhavar G and Chatpalliwar VA. Quantitative Analysis of Propranolol Hydrochloride by High Performance Thin Layer Chromatography. Indian J Pharm Sci. 2008;70: 395–398.
- Salle ED, Baker KM, Bareggi SR, Watkins WD, Chidsey CA, Frigerio A, Morselli PL. A sensitive gas chromatographic method for the determination of propranolol in human plasma. Journal of Chromatography A, 1973; 84:347-353.
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