Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Synthesis, Characterization and Antimicrobial activity of Some Flavones


Affiliations
1 Dept. of Chemistry, Bapatla Engineering College, Bapatla (Autonomous)-522101, Andhra Pradesh, India
2 Dept. of Chemistry, St’Anna’s Engineering College, Chirala -523156, Andhra Pradesh, India
     

   Subscribe/Renew Journal


Flavonoids are ubiquitous in photo synthesizing cells and are commonly found in fruit, vegetables, nuts, seeds, stems, flowers, tea, wine, propolis and honey. For centuries, preparations containing these compounds as the principle physiologically active constituents have been used to treat human diseases. These are abundant in polygonaceae, rutaceae, leguminosae, umbelliferae and compositae. 2(subtituted phenyl) - 4H- Chromen - 4 - one's were synthesized from substituted chalcones. The compounds obtained were identified by spectral data and screened for antimicrobial activity.

Keywords

Chalcone, synthesis, flavonoids, antimicrobial activity, IR and 1H-NMR Spectral Data
Subscription Login to verify subscription
User
Notifications
Font Size


  • Amic D, Davidovic-Amic D, Beslo D, Rastija V, Lucic B and Trinajstic N. SAR and QSAR of the antioxidant activity of flavonoids. Curr Med Chem.14 (7); 2007: 827-845.
  • Pietta PG. Flavonoids as antioxidants. J Nal Prod. 63(7); 2000: 1035-1042.
  • Kim HP, Son KH, Chang HW and Kang SK. Anti-inflammatory plant flavonoids and cellular action mechanisms. J Pharmacol Sci. 96; 2004: 229-245.
  • Mills S and Bone K. Principles and practice of phytotherapy- Modern Herbal Medicine. New York: Churchill Livingstone. 2000: 31-34.
  • Rice-Evans CA, Miller NJ and Paganga G. Structure – antioxidant activity relationship of flavonoids and phenolic acids. Free Rad Bio Med. 20(7); 1996: 933-956.
  • Rice-Evans C. Flavonoids as antioxidants. Curr Med Chem. 8(7); 2001: 797-807.
  • Pietta PG. Flavonoids as antioxidants. J Nat Prod. 63(7); 2000: 1035-1042.
  • Chan ECH, Patchareewan P and Owen LW. Relaxation to flavonols in rat isolated thoracic aorta: Mechanism of action and structure activity relationships. J Cardiovasc Pharmacol.35 (2); 2000: 326-333.
  • De Almeida ER, Xavier HS, Chaves TM, Couto GBC, Aragao- Neto AC, Silva AR and Da Silva LLS. Anxiolytic and anticonvulsant effect of dioclenol flavonoids isolated from stem bark of dioclea grandiflora on mice. International journal of Applied Research and Natural Products. 2(4); 2009-10: 44-51.
  • Shin JS, Kim KS, Kim MB, Joeng JH and Kim BK. Synthesis and hypoglycemic effect of chrysin derivatives. Bioorg Med Chem Lett. 9(6); 1999: 869-874.
  • Proestos C, Boziaris IS and Nychas JE. Analysis of Flavonoids and Phenolic Acids in Greek Aromatic Plants:Investigation of their Antioxidant capacity and antimicrobial activity. Food Chem. 93; 2005: 1998-2004.
  • Yenjai C, Prasanphen K, Daodee S and Kittakoop P. Bioactive flavonoids from Kaempherilia Parviflora. Fitoterapia. 75; 2004: 89-92.
  • Xia Y, Yang ZY, Xia P, Bastow KF, Nakanishi Y and Lee KH. Antitumor agents. Part 202: Novel 2’-Amino Chalcones: Desing, Synthesis and Biological Evaluation. Bioorganic and Medicinal Chemistry Letters.10; 2000: 699-701.
  • Kumar KH and Perumal PT. A novel one-pot oxidative cyclization of 2’-amino and 2’-hydroxyl chalcones employing FeCl3.6H2O-Methanol. Synthesis of 4-alkoxy-2-aryl-quinolines and flavones. Tetrahedron. 63(38); 2007: 9531-9535.
  • Ballesteros JF, Sanz MJ, Ubeda A, Miranda MA, Iborra S, Paya M and Alcaraz MJ. Synthesis and pharmacological evaluation of 2-hydroxy chalcones and flavones as inhibitors of inflammatory Mediators. J Med Chem. 38(14); 1995: 2794-2797.
  • Varma RS, Saini RK and Kumar D. An Expeditious Synthesis of Flavones on Montmorillonite K- 10 Clay with microwaves. J Chem Res (S). 30(13); 1999: 348-349.
  • Miao H and Yang Z. Regiospecific carbonylative annulations of iodophenol acetates and acetylenes to construct the flavones by a new catalyst of palladium-thiourea-dppp complex. Org Lett. 2(12); 2000: 1765-1768.
  • Bennerdi DO, Romanelli GP, Jios JL, Autino JC, Baronetti GT and Thomas HJ. Synthesis of substituted flavones and chromens using a Wells-Dawson heteropoly acid as catalyst. Arkivoc. XI; 2008: 123-130.
  • Saisivam S and Kishan VB. Standard method of antifungal activity. Ind J. Microbio. 46 (2); 2006: 13-19.
  • Wader SJ, Tapas AR and Yeole PG. Studies on synthesis and antioxidant activity of some new flavonols. Int J Chem Sci. 4(4); 2006: 761-766.

Abstract Views: 344

PDF Views: 5




  • Synthesis, Characterization and Antimicrobial activity of Some Flavones

Abstract Views: 344  |  PDF Views: 5

Authors

K. Prasada Rao
Dept. of Chemistry, Bapatla Engineering College, Bapatla (Autonomous)-522101, Andhra Pradesh, India
K. Santha Kumari
Dept. of Chemistry, St’Anna’s Engineering College, Chirala -523156, Andhra Pradesh, India
S. Mohan
Dept. of Chemistry, Bapatla Engineering College, Bapatla (Autonomous)-522101, Andhra Pradesh, India

Abstract


Flavonoids are ubiquitous in photo synthesizing cells and are commonly found in fruit, vegetables, nuts, seeds, stems, flowers, tea, wine, propolis and honey. For centuries, preparations containing these compounds as the principle physiologically active constituents have been used to treat human diseases. These are abundant in polygonaceae, rutaceae, leguminosae, umbelliferae and compositae. 2(subtituted phenyl) - 4H- Chromen - 4 - one's were synthesized from substituted chalcones. The compounds obtained were identified by spectral data and screened for antimicrobial activity.

Keywords


Chalcone, synthesis, flavonoids, antimicrobial activity, IR and 1H-NMR Spectral Data

References