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Synthesis of Some Novel 2,5-Disubstituted 1,3,4-Oxadiazole Derivatives as Potential Antibacterial and Anti-inflammatory activity


Affiliations
1 Kamla Nehru Institute of Management and Technology (Faculty of Pharmacy), Sultanpur-228001(U.P.), India
     

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A novel series of 2-Amidino-5-aryl-1,3,4-oxadiazole derivatives (N1-N4) have been synthesized. A mixture of 2- Amino-5-aryl-1,3,4-oxadiazole, powdered anhydrous aluminium chloride and acetonitrile heated in an oil bath keeping the temperature at 150-160°C for 2 hours to synthesize the derivatives (N1-N4). The structures of newly synthesized compounds were established on the basis of FT- IR, 1H NMR and Mass spectroscopic techniques. The newly synthesized compounds were screened for their in vitro antibacterial activity and in vivo anti- inflammatory activity. In vitro anti-bacterial activity was evaluated by Disc Diffusion technique against Ofloxacin used as standard drug. In vivo anti-inflammatory activity was determined by Carageenan Induced Rat Paw Oedema method against Ibuprofen used as standard drug. Compounds N1 and N2 exhibited good antibacterial activity, compound N4 showed moderate antibacterial activity and compound N3 showed poor antibacterial activity. Compound N4 showed good antiinflammatory activity, compounds N1 and N3 showed moderate anti-inflammatory activity and compound N2 showed poor anti-inflammatory activity.

Keywords

1,3,4-oxadiazole, Antibacterial Activity, Anti-inflammatory Activity
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  • Synthesis of Some Novel 2,5-Disubstituted 1,3,4-Oxadiazole Derivatives as Potential Antibacterial and Anti-inflammatory activity

Abstract Views: 303  |  PDF Views: 2

Authors

Nupur Jaiswal
Kamla Nehru Institute of Management and Technology (Faculty of Pharmacy), Sultanpur-228001(U.P.), India
Arvind Kr. Singh
Kamla Nehru Institute of Management and Technology (Faculty of Pharmacy), Sultanpur-228001(U.P.), India

Abstract


A novel series of 2-Amidino-5-aryl-1,3,4-oxadiazole derivatives (N1-N4) have been synthesized. A mixture of 2- Amino-5-aryl-1,3,4-oxadiazole, powdered anhydrous aluminium chloride and acetonitrile heated in an oil bath keeping the temperature at 150-160°C for 2 hours to synthesize the derivatives (N1-N4). The structures of newly synthesized compounds were established on the basis of FT- IR, 1H NMR and Mass spectroscopic techniques. The newly synthesized compounds were screened for their in vitro antibacterial activity and in vivo anti- inflammatory activity. In vitro anti-bacterial activity was evaluated by Disc Diffusion technique against Ofloxacin used as standard drug. In vivo anti-inflammatory activity was determined by Carageenan Induced Rat Paw Oedema method against Ibuprofen used as standard drug. Compounds N1 and N2 exhibited good antibacterial activity, compound N4 showed moderate antibacterial activity and compound N3 showed poor antibacterial activity. Compound N4 showed good antiinflammatory activity, compounds N1 and N3 showed moderate anti-inflammatory activity and compound N2 showed poor anti-inflammatory activity.

Keywords


1,3,4-oxadiazole, Antibacterial Activity, Anti-inflammatory Activity

References