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Syntheses of Some Novel 1,3,4-Oxadiazole Derivatives and their Potential Biological Activity


Affiliations
1 Nadkarny-Sacasa Research Laboratory, Department of Chemistry, St. Xavier’s College, Mumbai - 400 001
     

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A new Mannich base of quinazolin-4-one derivatives possessing 1,3,4-oxadiazole ring have been synthesized by reacting 3-[4-(5-thioxo-4,5-dihydro-[1,3,4]oxadiazole-2-yl)-phenyl]-2-phenyl-3H-quinazolin-4-one (4) with different secondary amines and formaldehyde using N,N-dimethylformamide as the solvent to afford 3-[4-(4-substituted amino- 4-ylmethyl-5-thioxo-4,5-dihydro-[1,3,4]oxadiazole-2-yl)-phenyl]-2-phenyl-3H-quinazolin-4-ones (5a-e). The structures of the newly synthesized compounds have been established by analytical and spectral methods. The compounds have also been screened for their biological activity.

Keywords

Synthesis, Oxadiazole, Antibacterial And Antifungal Activity
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  • Syntheses of Some Novel 1,3,4-Oxadiazole Derivatives and their Potential Biological Activity

Abstract Views: 238  |  PDF Views: 2

Authors

Freddy H. Havaldar
Nadkarny-Sacasa Research Laboratory, Department of Chemistry, St. Xavier’s College, Mumbai - 400 001
Azadkumar S. Sharma
Nadkarny-Sacasa Research Laboratory, Department of Chemistry, St. Xavier’s College, Mumbai - 400 001

Abstract


A new Mannich base of quinazolin-4-one derivatives possessing 1,3,4-oxadiazole ring have been synthesized by reacting 3-[4-(5-thioxo-4,5-dihydro-[1,3,4]oxadiazole-2-yl)-phenyl]-2-phenyl-3H-quinazolin-4-one (4) with different secondary amines and formaldehyde using N,N-dimethylformamide as the solvent to afford 3-[4-(4-substituted amino- 4-ylmethyl-5-thioxo-4,5-dihydro-[1,3,4]oxadiazole-2-yl)-phenyl]-2-phenyl-3H-quinazolin-4-ones (5a-e). The structures of the newly synthesized compounds have been established by analytical and spectral methods. The compounds have also been screened for their biological activity.

Keywords


Synthesis, Oxadiazole, Antibacterial And Antifungal Activity

References