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Synthesis, Characterization and Biological Screening of some Newer Carbazole Conjugates


Affiliations
1 Department of Chemistry, Faculty of Science and IT, Madhyanchal Professional University, Ratibad - 462044, Bhopal - Madhya Pradesh, India, India
2 Department of Chemistry, Government College, Khurai - 470117, Madhya Pradesh., India
     

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A novel series of novel 5-[(9H-carbazol-9-yl)methyl]-N-[(substituted phenyl)(piperazin-1-yl)methyl]-1,3,4- oxadiazol-2-amines (4a–o) products were synthesized from starting material of carbazole, which were on reacted with ethyl chloro-acetate yielded to form ethyl 2-(9H-carbazole-9-yl)acetate (1). Compound 1 on reacted with semicarbazide followed by cyclisation by sulphuric acid to give 5-((9H-carbazole-9-yl)-1,3,4-oxadiazol-2- amine (3), which through Mannich condensation with piperazine and a variety of aromatic aldehydes in the occurrence of acetic acid to form titled compounds (4a–o). The structures of compounds were characterized by UV, FT-IR, 1H-NMR and MS spectral studies, and by elemental analysis.

Keywords

Mannich reaction, Anti-epileptic Activity, MEZ Method, Carbazole
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  • Synthesis, Characterization and Biological Screening of some Newer Carbazole Conjugates

Abstract Views: 61  |  PDF Views: 0

Authors

Neetu Verma
Department of Chemistry, Faculty of Science and IT, Madhyanchal Professional University, Ratibad - 462044, Bhopal - Madhya Pradesh, India, India
Shruti Awasthi
Department of Chemistry, Government College, Khurai - 470117, Madhya Pradesh., India
Vikrant Jain
Department of Chemistry, Government College, Khurai - 470117, Madhya Pradesh., India

Abstract


A novel series of novel 5-[(9H-carbazol-9-yl)methyl]-N-[(substituted phenyl)(piperazin-1-yl)methyl]-1,3,4- oxadiazol-2-amines (4a–o) products were synthesized from starting material of carbazole, which were on reacted with ethyl chloro-acetate yielded to form ethyl 2-(9H-carbazole-9-yl)acetate (1). Compound 1 on reacted with semicarbazide followed by cyclisation by sulphuric acid to give 5-((9H-carbazole-9-yl)-1,3,4-oxadiazol-2- amine (3), which through Mannich condensation with piperazine and a variety of aromatic aldehydes in the occurrence of acetic acid to form titled compounds (4a–o). The structures of compounds were characterized by UV, FT-IR, 1H-NMR and MS spectral studies, and by elemental analysis.

Keywords


Mannich reaction, Anti-epileptic Activity, MEZ Method, Carbazole

References