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A Validated Reverse Phase HPLC Method for the Simultaneous Estimation of Atorvastatin Calcium and Ezetimibe in Pharmaceutical Dosage Forms


Affiliations
1 Hindu College of Pharmacy, Amaravathi Road, Guntur-522002 (Andhra Pradesh), India
2 Department of Environmental Sciences, Acharya Nagarjuna University, Nagarjuna Nagar, India
3 University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, India
     

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A simple, sensitive and precise reverse phase high performance liquid chromatographic method has been developed for the simultaneous estimation of Atorvastatin calcium and Ezetimibe in pharmaceutical dosage forms. The mobile phase consisted of Acetonitrile: buffer (0.1% v/v ortho phosphoric acid, PH-6) in the ratio 60:40 delivered at a flow rate of 1 ml/min and wavelength of detection at 232 nm. The retention times of Atorvastatin calcium and Ezetimibe were 3.7 min and 6.1 min respectively. The developed method was validated according to ICH guidelines. The proposed method can be used for determination of these drugs in combined dosage forms.

Keywords

Atorvastatin Calcium, Ezetimibe, RP-HPLC.
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  • A Validated Reverse Phase HPLC Method for the Simultaneous Estimation of Atorvastatin Calcium and Ezetimibe in Pharmaceutical Dosage Forms

Abstract Views: 169  |  PDF Views: 0

Authors

P. Nagaraju
Hindu College of Pharmacy, Amaravathi Road, Guntur-522002 (Andhra Pradesh), India
Z. Vishnu Vardhan
Department of Environmental Sciences, Acharya Nagarjuna University, Nagarjuna Nagar, India
J. V. L. N. Seshagiri Rao
University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, India

Abstract


A simple, sensitive and precise reverse phase high performance liquid chromatographic method has been developed for the simultaneous estimation of Atorvastatin calcium and Ezetimibe in pharmaceutical dosage forms. The mobile phase consisted of Acetonitrile: buffer (0.1% v/v ortho phosphoric acid, PH-6) in the ratio 60:40 delivered at a flow rate of 1 ml/min and wavelength of detection at 232 nm. The retention times of Atorvastatin calcium and Ezetimibe were 3.7 min and 6.1 min respectively. The developed method was validated according to ICH guidelines. The proposed method can be used for determination of these drugs in combined dosage forms.

Keywords


Atorvastatin Calcium, Ezetimibe, RP-HPLC.