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Spectrophotometric Estimation of Rizatriptan Benzoate


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1 Maulana Azad Educational Trust’s Y.B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Rauza Bagh, Aurangabad-431001 (MS), India
     

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A simple, sensitive, rapid, precise, cost effective and reproducible UV spectrophotometric method has been developed for estimation of Rizatriptan Benzoate in bulk and tablet dosage form. Rizatriptan benzoate shows maximum absorbance at 225 nm with molar absorptivity of 8.9583×104 l/mol.cm. Beer's law was obeyed in the concentration range of 1-10 μg/ml. Results of analysis were validated by statistical analysis and by recovery studies. The method was validated with respect to linearity, precision, LOD, LOQ, Sandell’s sensitivity and specificity. The proposed method was found to be accurate and precise for routine estimation of Rizatriptan Benzoate in bulk and tablet dosage forms.

Keywords

UV Spectrophotometer, Rizatriptan Benzoate.
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  • Spectrophotometric Estimation of Rizatriptan Benzoate

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Authors

Vivek Rajendra
Maulana Azad Educational Trust’s Y.B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Rauza Bagh, Aurangabad-431001 (MS), India
Amol Khedkar
Maulana Azad Educational Trust’s Y.B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Rauza Bagh, Aurangabad-431001 (MS), India
Alpana Kulkarni
Maulana Azad Educational Trust’s Y.B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Rauza Bagh, Aurangabad-431001 (MS), India
Mohd. Hassan G. Dehghan
Maulana Azad Educational Trust’s Y.B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Rauza Bagh, Aurangabad-431001 (MS), India
Maria Saifee
Maulana Azad Educational Trust’s Y.B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Rauza Bagh, Aurangabad-431001 (MS), India
Swaroop Lahoti
Maulana Azad Educational Trust’s Y.B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Rauza Bagh, Aurangabad-431001 (MS), India

Abstract


A simple, sensitive, rapid, precise, cost effective and reproducible UV spectrophotometric method has been developed for estimation of Rizatriptan Benzoate in bulk and tablet dosage form. Rizatriptan benzoate shows maximum absorbance at 225 nm with molar absorptivity of 8.9583×104 l/mol.cm. Beer's law was obeyed in the concentration range of 1-10 μg/ml. Results of analysis were validated by statistical analysis and by recovery studies. The method was validated with respect to linearity, precision, LOD, LOQ, Sandell’s sensitivity and specificity. The proposed method was found to be accurate and precise for routine estimation of Rizatriptan Benzoate in bulk and tablet dosage forms.

Keywords


UV Spectrophotometer, Rizatriptan Benzoate.