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UV Spectrophotometric Determination of Norethisterone in Tablets


Affiliations
1 Department of Pharmaceutical Analysis, The Erode College of Pharmacy, Veppampalayam, Erode-638112, TN, India
     

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A new simple, sensitive, precise and economical spectrophotometric method of analysis for a bulk drug was developed and validated. The method employed methanol as solvent. The drug was then estimated at 270 nm. The linear regression analysis data for the calibration plots showed good linear relationship with r2=0.999 in the concentration range 0.5-3.0 μg/ml. The mean value of correlation coefficient, slope and intercept were 0.999, 0.0332 and 0.0002 respectively. The method was validated for precision, accuracy and recovery studies. LOD and LOQ for norethisterone was found to be 0.01987 (μg/ml) and 0.06024 (μg/ml) respectively. The method has been successfully applied in the analysis of marketed formulations.

Keywords

Norethisterone, UV Spectrophotometric Analysis.
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  • UV Spectrophotometric Determination of Norethisterone in Tablets

Abstract Views: 166  |  PDF Views: 0

Authors

A. Rama Chandra Reddy
Department of Pharmaceutical Analysis, The Erode College of Pharmacy, Veppampalayam, Erode-638112, TN, India
K. Roshna
Department of Pharmaceutical Analysis, The Erode College of Pharmacy, Veppampalayam, Erode-638112, TN, India
P. Mohanraj
Department of Pharmaceutical Analysis, The Erode College of Pharmacy, Veppampalayam, Erode-638112, TN, India
T. M. Kulanthavel
Department of Pharmaceutical Analysis, The Erode College of Pharmacy, Veppampalayam, Erode-638112, TN, India
V. S. Saravanan
Department of Pharmaceutical Analysis, The Erode College of Pharmacy, Veppampalayam, Erode-638112, TN, India
V. Ganesh
Department of Pharmaceutical Analysis, The Erode College of Pharmacy, Veppampalayam, Erode-638112, TN, India

Abstract


A new simple, sensitive, precise and economical spectrophotometric method of analysis for a bulk drug was developed and validated. The method employed methanol as solvent. The drug was then estimated at 270 nm. The linear regression analysis data for the calibration plots showed good linear relationship with r2=0.999 in the concentration range 0.5-3.0 μg/ml. The mean value of correlation coefficient, slope and intercept were 0.999, 0.0332 and 0.0002 respectively. The method was validated for precision, accuracy and recovery studies. LOD and LOQ for norethisterone was found to be 0.01987 (μg/ml) and 0.06024 (μg/ml) respectively. The method has been successfully applied in the analysis of marketed formulations.

Keywords


Norethisterone, UV Spectrophotometric Analysis.