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An Efficient One Pot Synthesis of Fused Pyrazolo [3’, 4’:4, 5] Pyrimido [2,1-b][1,3] Benzothiazole and its 2-Substituted Derivatives


Affiliations
1 P. G. Department of Organic Chemistry, Yeshwant Mahavidyalaya, Nanded-431602, India
2 Department of Organic Chemistry, N.S.B. College, Nanded-431605, India
     

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Pyrazolo pyrimido benzothiazoles (4a-i) were prepared by the reaction of compound 3-cyano-4-imino-2-methylthio-8-methyl-4H-pyrimido[2,1-b] benzothiazole (3) with hydrazine hydrate, substituted phenyl hydrazine, 2-hydrazino benzothiazole and 6-substituted 2-hydrazino benzothiazole in N,N-dimethyl formamide and catalytic amount of potassium carbonate. The synthesized compounds were characterized by elemental analysis, IR, PMR and Mass data.

Keywords

N,N-Dimethyl Formamide, Potassium Carbonate, Pyrimodo Benzothiazole, Pyrazole.
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  • An Efficient One Pot Synthesis of Fused Pyrazolo [3’, 4’:4, 5] Pyrimido [2,1-b][1,3] Benzothiazole and its 2-Substituted Derivatives

Abstract Views: 161  |  PDF Views: 0

Authors

Sambhaji P. Vartale
P. G. Department of Organic Chemistry, Yeshwant Mahavidyalaya, Nanded-431602, India
Vijay N. Bhosale
P. G. Department of Organic Chemistry, Yeshwant Mahavidyalaya, Nanded-431602, India
Sharad V. Kuberkar
P. G. Department of Organic Chemistry, Yeshwant Mahavidyalaya, Nanded-431602, India
Jagannath S. Jadhav
Department of Organic Chemistry, N.S.B. College, Nanded-431605, India

Abstract


Pyrazolo pyrimido benzothiazoles (4a-i) were prepared by the reaction of compound 3-cyano-4-imino-2-methylthio-8-methyl-4H-pyrimido[2,1-b] benzothiazole (3) with hydrazine hydrate, substituted phenyl hydrazine, 2-hydrazino benzothiazole and 6-substituted 2-hydrazino benzothiazole in N,N-dimethyl formamide and catalytic amount of potassium carbonate. The synthesized compounds were characterized by elemental analysis, IR, PMR and Mass data.

Keywords


N,N-Dimethyl Formamide, Potassium Carbonate, Pyrimodo Benzothiazole, Pyrazole.