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UV Spectrophotometric Determination of Risperidone in Bulk and its Formulation


Affiliations
1 Dept. of Pharmaceutical Analysis, Hindu College of Pharmacy, Amaravathi Road, Guntur-2, A.P, India
2 Dept. of Pharmaceutical Analysis, KVSR Siddhartha College of Pharmacy, Vijayawada-10, A.P, India
3 Dept. of Chemical Engineering, JNTU College of Engineering, Anantapur-515002, A.P, India
     

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A simple, sensitive and economical UV spectrophotometric method has been developed for the determination of Risperidone in bulk and tablet dosage forms. Risperidone is an anti-psychotic drug, which shows maximum absorbance at 238 nm in 0.1 N HCl. Beer’s law was obeyed in the concentration range of 5-30 μg/ml with correlation coefficient of 0.9999.The standard plot clearly showed a straight line passing through the origin. The results of analysis were validated statistically and by recovery studies and found to be satisfactory. The proposed method was extended to pharmaceutical formulations and there was no interference of additives and excipients.

Keywords

Risperidone, UV Spectrophotometric, Tablet Dosage Form.
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  • UV Spectrophotometric Determination of Risperidone in Bulk and its Formulation

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Authors

S. Kathirvel
Dept. of Pharmaceutical Analysis, Hindu College of Pharmacy, Amaravathi Road, Guntur-2, A.P, India
G. Devala Rao
Dept. of Pharmaceutical Analysis, KVSR Siddhartha College of Pharmacy, Vijayawada-10, A.P, India
S. V. Satyanarayana
Dept. of Chemical Engineering, JNTU College of Engineering, Anantapur-515002, A.P, India

Abstract


A simple, sensitive and economical UV spectrophotometric method has been developed for the determination of Risperidone in bulk and tablet dosage forms. Risperidone is an anti-psychotic drug, which shows maximum absorbance at 238 nm in 0.1 N HCl. Beer’s law was obeyed in the concentration range of 5-30 μg/ml with correlation coefficient of 0.9999.The standard plot clearly showed a straight line passing through the origin. The results of analysis were validated statistically and by recovery studies and found to be satisfactory. The proposed method was extended to pharmaceutical formulations and there was no interference of additives and excipients.

Keywords


Risperidone, UV Spectrophotometric, Tablet Dosage Form.