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Synthesis and Biological Evaluation of Amides of Aminothiazole Derivatives


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1 Department of Applied Chemistry, The M. S. University of Baroda, Vadodara-390001, India
     

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Condensation of acetophenone with thiourea in presence of Iodine gives 2-amino-4-phenylthiazole (I). 4-(2-Amino-4- phenyl-thiazol-5-yl-azo)-benzoic acid ethyl ester (III) was prepared by coupling of 4-ethoxycarbonylphenyldiazonium chloride with 2-amino-4-phenylthiazole. A series of amide (V) can be synthesized by treatment of appropriate substituted acid chlorides with compound (III) using pyridine as solvent. All the synthesized compounds are characterized by the combination of elemental analysis and standard spectroscopic method. They are screened for anti-bacterial activity against Escherichia coli and Staphylococcus aureus as well as screened for antifungal activity against aspergillus niger and apergillus oryzae by cup plate method at 1 μg/mL concentration in DMF. All the synthesized compounds showed moderate or good microbial activity.

Keywords

Aminothiazoles, Synthesis, Characterization, Antibacterial and Antifungal Activity.
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  • Synthesis and Biological Evaluation of Amides of Aminothiazole Derivatives

Abstract Views: 138  |  PDF Views: 0

Authors

A. K. Prajapati
Department of Applied Chemistry, The M. S. University of Baroda, Vadodara-390001, India
Vishal P. Modi
Department of Applied Chemistry, The M. S. University of Baroda, Vadodara-390001, India

Abstract


Condensation of acetophenone with thiourea in presence of Iodine gives 2-amino-4-phenylthiazole (I). 4-(2-Amino-4- phenyl-thiazol-5-yl-azo)-benzoic acid ethyl ester (III) was prepared by coupling of 4-ethoxycarbonylphenyldiazonium chloride with 2-amino-4-phenylthiazole. A series of amide (V) can be synthesized by treatment of appropriate substituted acid chlorides with compound (III) using pyridine as solvent. All the synthesized compounds are characterized by the combination of elemental analysis and standard spectroscopic method. They are screened for anti-bacterial activity against Escherichia coli and Staphylococcus aureus as well as screened for antifungal activity against aspergillus niger and apergillus oryzae by cup plate method at 1 μg/mL concentration in DMF. All the synthesized compounds showed moderate or good microbial activity.

Keywords


Aminothiazoles, Synthesis, Characterization, Antibacterial and Antifungal Activity.