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Estimation of Gatifloxacin in Tablet Dosage Form by Spectrofluorimetric Method


Affiliations
1 Veerayatan Institute of Pharmacy, Jakhania Bhuj, Mandvi Road, Mandvi-370640, India
2 Babaria Institute of Pharmacy, Vadodara-391240, India
3 Jiladia Hospital, New Anjar, Anjar (Kutch)-370110, India
     

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Three simple and sensitive spectrofluorimetric methods have been developed for the determination of gatifloxacin and its tablet dosage forms. In fluorescence spectrum of gatifloxacin exhibit excitation and emission wavelength at 295 and 498 nm in hydrochloric acid, 295 and 489 nm in acetate buffer pH-4 and 337 and 488 nm, in phthalate buffer pH-4, respectively. The fluorescence intensity for all three methods was found to be linear with the concentration in the range of 200-1000 ng/ml. The % recovery for gatifloxacin was found in the range of 97.0-102.6% in hydrochloric acid, 99.5-100.2% in acetate buffer, 98.3–100.1% in phthalate buffer. These methods were found to be simple, accurate, reproducible and economical and can be used for the routine analysis of gatifloxacin in bulk drug and its tablets.

Keywords

Gatifloxacin, Hydrochloric Acid, Acetate Buffer, Phthalate Buffer pH-4.
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  • Estimation of Gatifloxacin in Tablet Dosage Form by Spectrofluorimetric Method

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Authors

Meeta A. Jiladia
Veerayatan Institute of Pharmacy, Jakhania Bhuj, Mandvi Road, Mandvi-370640, India
S. S. Pandya
Babaria Institute of Pharmacy, Vadodara-391240, India
Ashok G. Jiladia
Jiladia Hospital, New Anjar, Anjar (Kutch)-370110, India

Abstract


Three simple and sensitive spectrofluorimetric methods have been developed for the determination of gatifloxacin and its tablet dosage forms. In fluorescence spectrum of gatifloxacin exhibit excitation and emission wavelength at 295 and 498 nm in hydrochloric acid, 295 and 489 nm in acetate buffer pH-4 and 337 and 488 nm, in phthalate buffer pH-4, respectively. The fluorescence intensity for all three methods was found to be linear with the concentration in the range of 200-1000 ng/ml. The % recovery for gatifloxacin was found in the range of 97.0-102.6% in hydrochloric acid, 99.5-100.2% in acetate buffer, 98.3–100.1% in phthalate buffer. These methods were found to be simple, accurate, reproducible and economical and can be used for the routine analysis of gatifloxacin in bulk drug and its tablets.

Keywords


Gatifloxacin, Hydrochloric Acid, Acetate Buffer, Phthalate Buffer pH-4.