Asian Journal of Research in Chemistry

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Synthesis and Antimicrobial Evaluation of Benzimidazole Analogs


Affiliations
1 Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Parel, Mumbai-12, India
     

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A series of benzimidazole phenylthiocarbamoyl derivatives were synthesized by condensing substituted 2-mercaptobenzimidazole with substituted benzoyl chlorides. These benzimidazole derivatives were evaluated for their antibacterial activity against Gram Positive bacteria Staphylococcus aureus (ATCC 3750) and Gram Negative bacteria Salmonella typhi (NCTC 786), as well as antifungal activity against a fungal strain Candida albicans (ATCC 10231). It was observed that the 5-naphthoxy-6-chloro benzimidazole derivatives having dichloro substitutions on the phenylthiocarbamoyl part of the molecule showed better activity than the rest.

Keywords

Benzimidazole, Antimicrobial, Phenylthiocarbamoyl Derivatives, Benzoyl Chloride.
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  • Synthesis and Antimicrobial Evaluation of Benzimidazole Analogs

Abstract Views: 159  |  PDF Views: 0

Authors

Y. S. Rane
Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Parel, Mumbai-12, India
R. R. Varma
Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Parel, Mumbai-12, India
L. S. Patil
Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Parel, Mumbai-12, India
S. V. Athlekar
Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Parel, Mumbai-12, India
A. S. Chowdhary
Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Parel, Mumbai-12, India
A. S. Bobade
Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Parel, Mumbai-12, India

Abstract


A series of benzimidazole phenylthiocarbamoyl derivatives were synthesized by condensing substituted 2-mercaptobenzimidazole with substituted benzoyl chlorides. These benzimidazole derivatives were evaluated for their antibacterial activity against Gram Positive bacteria Staphylococcus aureus (ATCC 3750) and Gram Negative bacteria Salmonella typhi (NCTC 786), as well as antifungal activity against a fungal strain Candida albicans (ATCC 10231). It was observed that the 5-naphthoxy-6-chloro benzimidazole derivatives having dichloro substitutions on the phenylthiocarbamoyl part of the molecule showed better activity than the rest.

Keywords


Benzimidazole, Antimicrobial, Phenylthiocarbamoyl Derivatives, Benzoyl Chloride.