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Synthesis and Screening of Biphenyl Ether Derivatives for their Anti-Inflammatory and Analgesic Activity
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Nimesulide (Biphenyl Ether) derivatives were synthesized by four steps, Step-1-Ulmaan ether synthesis, Step-2-Reduction of NO2, Step-3-Condensation reaction, Step-4-Nitration and evaluated for their anti-inflammatory and analgesic activities.
The compounds have been characterized on the basis of preliminary methods, spectral data and tested for anti-inflammatory activity and compared with standard drug as per the standard drug rat hind paw edema method by using Plethesimograph and analgesic activity by Eddies-hotplate method. Among the derivatives prepared, few showed the moderate activity and few showed decreased activity.
The compounds have been characterized on the basis of preliminary methods, spectral data and tested for anti-inflammatory activity and compared with standard drug as per the standard drug rat hind paw edema method by using Plethesimograph and analgesic activity by Eddies-hotplate method. Among the derivatives prepared, few showed the moderate activity and few showed decreased activity.
Keywords
Biphenyl Ether Derivatives, Phenoxy Methane Sulphonamide Derivatives, Non-Steroidal Anti-Inflammatory and Analgesic Drugs.
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