Asian Journal of Research in Chemistry

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Synthesis and Analgesic Activity of 2, 5 Di-Substituted 1, 3, 4 Oxadiazoles


Affiliations
1 Dept. of Pharmacy, Pranveer Singh Institute of Technology, Kalpi Road, Bhauti, Kanpur-08020, (U. P.), India
2 Department of Pharmacy, Aligarh College of Pharmacy, Aligarh (U.P), India
3 Department of Pharmacy, Allahabad Agriculture Deemed University, Allahabad (U.P), India
     

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1, 2, 3 benzotriazole derivative also show several pharmacological activities viz.example. Antimicrobial activity, Anti inflammatory, Anti analgesic activity, Anticancer etc. On the basis of our observation the parent research work was carried out to synthesize 1, 2, 3 triazole substituted 1, 3, 4 oxadiazoles and to further evaluate Analgesic activity. Synthesis of (ethyl 2- (1H Benzo [d] [1, 2, 3] triazole-1-yl] acetate) and (2H-benzo [d] [1,2,3] triazole-1-yl aceto hydrazine) along with their derivatives has been done. The entire synthesized compounds were characterized by UV, IR and 1H-NMR specteoscopy. The Antimicrobial activity of the synthesized compounds was evaluated, on albino rats. The present investigation deals with the synthesized compounds possessing good Analgesic activity.

Keywords

Hydrazine, Benztriazole, Analgesic Activity.
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  • Synthesis and Analgesic Activity of 2, 5 Di-Substituted 1, 3, 4 Oxadiazoles

Abstract Views: 149  |  PDF Views: 0

Authors

Rakesh Saini
Dept. of Pharmacy, Pranveer Singh Institute of Technology, Kalpi Road, Bhauti, Kanpur-08020, (U. P.), India
Saurabh Chaturvedi
Dept. of Pharmacy, Pranveer Singh Institute of Technology, Kalpi Road, Bhauti, Kanpur-08020, (U. P.), India
A. N. Kesari
Dept. of Pharmacy, Pranveer Singh Institute of Technology, Kalpi Road, Bhauti, Kanpur-08020, (U. P.), India
Rijuved Garg
Department of Pharmacy, Aligarh College of Pharmacy, Aligarh (U.P), India
Amita Verma
Department of Pharmacy, Allahabad Agriculture Deemed University, Allahabad (U.P), India

Abstract


1, 2, 3 benzotriazole derivative also show several pharmacological activities viz.example. Antimicrobial activity, Anti inflammatory, Anti analgesic activity, Anticancer etc. On the basis of our observation the parent research work was carried out to synthesize 1, 2, 3 triazole substituted 1, 3, 4 oxadiazoles and to further evaluate Analgesic activity. Synthesis of (ethyl 2- (1H Benzo [d] [1, 2, 3] triazole-1-yl] acetate) and (2H-benzo [d] [1,2,3] triazole-1-yl aceto hydrazine) along with their derivatives has been done. The entire synthesized compounds were characterized by UV, IR and 1H-NMR specteoscopy. The Antimicrobial activity of the synthesized compounds was evaluated, on albino rats. The present investigation deals with the synthesized compounds possessing good Analgesic activity.

Keywords


Hydrazine, Benztriazole, Analgesic Activity.