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Diabinese and Nicotinic Acid Combination Reduced Cardiovascular Indices in Experimental Diabetes
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Background:Cardiovascular diseases with high levels of creatine kinase have been reported in diabetics as major killer, globally. Can single effect of diabinese(DB)- antidiabetic drug and combined effects of DB and nicotinic acid (NA)-a vitamin and an antilipidemic drug be used to manage diabetes and this associated cardiovascular disease?
Method:Dithizone induced-diabetic rabbits grouped into A, B, C, D and E were treated for 72 hrs with 10 mg DB, 10 mg DB/150 mg NA, 10 mgDB/200 mg NA, 10 mg DB/250 mg NA, and 5 ml of Distil water respectively.
Result:Dithizone increased the blood glucose, urea, creatinine and creatine kinase levels. Combined therapy of DB/NA did not affect the urea level but significantly (p<0.05) reduced the levels of glucose, creatinine and creatine kinase than in single therapy.
Conclusion:Combination of diabinese and nicotinic acid could be used to reduce the high levels of glucose, creatinine and creatine kinase associated with diabetes and cardiovascular disease.
Method:Dithizone induced-diabetic rabbits grouped into A, B, C, D and E were treated for 72 hrs with 10 mg DB, 10 mg DB/150 mg NA, 10 mgDB/200 mg NA, 10 mg DB/250 mg NA, and 5 ml of Distil water respectively.
Result:Dithizone increased the blood glucose, urea, creatinine and creatine kinase levels. Combined therapy of DB/NA did not affect the urea level but significantly (p<0.05) reduced the levels of glucose, creatinine and creatine kinase than in single therapy.
Conclusion:Combination of diabinese and nicotinic acid could be used to reduce the high levels of glucose, creatinine and creatine kinase associated with diabetes and cardiovascular disease.
Keywords
Diabinese, Nicotinic Acid, Diabetes, Cardiovascular Disease.
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