Asian Journal of Research in Chemistry

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Nanodrop Spectrophotometric Method for Estimation of Ranitidine Hydrochloride in Bulk and Tablet Dosage Form


Affiliations
1 College of Pharmaceutical Sciences, Mohuda, Berhampur, Orissa, India
2 Indira Gandhi Institute of Pharmaceutical Science, Bhubaneswar, Orissa, India
3 Biotech Park, Lucknow, Uttar Pradesh, India
     

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A novel, simple, sensitive and rapid nanodrop spectrophotometric method was developed for the estimation of Ranitidine hydrochloride in bulk and its pharmaceutical tablet dosage form. Ranitidine hydrochloride exhibiting maximum absorbance at 316 nm in distilled water and obeyed linearity in the concentration range of 5-100 ppm. The proposed method has been applied successfully for the analysis of Ranitidine hydrochloride either in bulk or pharmaceutical tablet dosage form with good accuracy and precision. The method herein described can be employed for quality control and routine analysis of Ranitidine hydrochloride in pharmaceutical tablet dosage form.

Keywords

Ranitidine Hydrochloride, Nanodrop Spectrophotometry, Maximum Absorbance, Bulk.
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  • Nanodrop Spectrophotometric Method for Estimation of Ranitidine Hydrochloride in Bulk and Tablet Dosage Form

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Authors

Singh Kumar Rakesh
College of Pharmaceutical Sciences, Mohuda, Berhampur, Orissa, India
S. Ramakrishna
College of Pharmaceutical Sciences, Mohuda, Berhampur, Orissa, India
Patel Singh Pankaj
Indira Gandhi Institute of Pharmaceutical Science, Bhubaneswar, Orissa, India
Gupta Pragya
Biotech Park, Lucknow, Uttar Pradesh, India

Abstract


A novel, simple, sensitive and rapid nanodrop spectrophotometric method was developed for the estimation of Ranitidine hydrochloride in bulk and its pharmaceutical tablet dosage form. Ranitidine hydrochloride exhibiting maximum absorbance at 316 nm in distilled water and obeyed linearity in the concentration range of 5-100 ppm. The proposed method has been applied successfully for the analysis of Ranitidine hydrochloride either in bulk or pharmaceutical tablet dosage form with good accuracy and precision. The method herein described can be employed for quality control and routine analysis of Ranitidine hydrochloride in pharmaceutical tablet dosage form.

Keywords


Ranitidine Hydrochloride, Nanodrop Spectrophotometry, Maximum Absorbance, Bulk.