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Simultaneous UV Spectrophotometric Method for Estimation of Fenofibrate and Metformine Hydrochloride in Tablet Dosage Form


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1 Department of Pharmacy, Sumandeep Vidyapeeth, Pipariya, Vadodara (391760), Gujarat, India
     

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A simple, accurate, precise, reproducible and economical procedure for simultaneous estimation of Fenofibrate (FENO) and Metformin hydrochloride (MET) in tablet dosage form as well as in bulk drugs have been developed using double beam UV Spectrophotometer. The method based on solving of simultaneous equation using 239 nm (λmax of FENO) and 218 nm (λmax of MET) as two analytical wavelengths for both drugs. The method was found to be linear in the range of 1 - 6 μgml-1 and 3.125-18.75 μgml-1 with mean recovery of 99.6 % and 101.82 % of fenofibrate and metformine hydrochloride, respectively. The solution of both drugs was prepared using Methanol as a solvent. The proposed method is suitable for simultaneous determination of Fenofibrate and Metformin hydrochloride in pharmaceutical dosage form.

Keywords

Fenofibrate, Metformine Hydrochloride, Methanol, U.V, Simultaneous Equation Method.
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  • Simultaneous UV Spectrophotometric Method for Estimation of Fenofibrate and Metformine Hydrochloride in Tablet Dosage Form

Abstract Views: 216  |  PDF Views: 0

Authors

Arpit Shah
Department of Pharmacy, Sumandeep Vidyapeeth, Pipariya, Vadodara (391760), Gujarat, India
Dhanya B. Sen
Department of Pharmacy, Sumandeep Vidyapeeth, Pipariya, Vadodara (391760), Gujarat, India
Ashim Kumar Sen
Department of Pharmacy, Sumandeep Vidyapeeth, Pipariya, Vadodara (391760), Gujarat, India
Sharad Kumar
Department of Pharmacy, Sumandeep Vidyapeeth, Pipariya, Vadodara (391760), Gujarat, India
Aarti Zanwar
Department of Pharmacy, Sumandeep Vidyapeeth, Pipariya, Vadodara (391760), Gujarat, India
Jayesh Bodar
Department of Pharmacy, Sumandeep Vidyapeeth, Pipariya, Vadodara (391760), Gujarat, India

Abstract


A simple, accurate, precise, reproducible and economical procedure for simultaneous estimation of Fenofibrate (FENO) and Metformin hydrochloride (MET) in tablet dosage form as well as in bulk drugs have been developed using double beam UV Spectrophotometer. The method based on solving of simultaneous equation using 239 nm (λmax of FENO) and 218 nm (λmax of MET) as two analytical wavelengths for both drugs. The method was found to be linear in the range of 1 - 6 μgml-1 and 3.125-18.75 μgml-1 with mean recovery of 99.6 % and 101.82 % of fenofibrate and metformine hydrochloride, respectively. The solution of both drugs was prepared using Methanol as a solvent. The proposed method is suitable for simultaneous determination of Fenofibrate and Metformin hydrochloride in pharmaceutical dosage form.

Keywords


Fenofibrate, Metformine Hydrochloride, Methanol, U.V, Simultaneous Equation Method.