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In Vitro Glucose Uptake Activity of Resveratrol by Upregulating the Expressions of GLUT 4, PI3 Kinase and PPARγ in L6 Myotubes


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1 Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600 025, India
     

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Resveratrol, a ubiquitous stress-induced polyphenolic phytoalexin has a wide variety of biological and pharmacological activities which make it a good candidate for the treatment of diabetes mellitus. However, most of the reports were conducted on in vivo models. There are no systematic studies to elucidate the underlying mechanism by which the resveratrol mediates its antihyperglycemic action. Hence, the present study was performed to study the effect of resveratrol on a battery of targets such as glucose transporter (GLUT4), phosphatidyl inositol 3' (PI3) kinase involved in glucose transport and peroxisome proliferator receptor gamma (PPAR γ) in L6 myotubes. The results of the present study indicate that an increase in the expressions of GLUT4, PI3 kinase in parallel with glucose uptake and PPARγ, supported the invitro glucose uptake activity of resveratrol. It is concluded that resveratrol mediates glucose transport in a PI3 kinase dependant fashion.

Keywords

Resveratrol, L6 Myotubes, Glucose Uptake, GLUT4, PPARγ, PI3 Kinase.
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  • In Vitro Glucose Uptake Activity of Resveratrol by Upregulating the Expressions of GLUT 4, PI3 Kinase and PPARγ in L6 Myotubes

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Authors

Sorimuthu Pillai Subramanian
Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600 025, India
Gopalan Sriram Prasath
Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600 025, India

Abstract


Resveratrol, a ubiquitous stress-induced polyphenolic phytoalexin has a wide variety of biological and pharmacological activities which make it a good candidate for the treatment of diabetes mellitus. However, most of the reports were conducted on in vivo models. There are no systematic studies to elucidate the underlying mechanism by which the resveratrol mediates its antihyperglycemic action. Hence, the present study was performed to study the effect of resveratrol on a battery of targets such as glucose transporter (GLUT4), phosphatidyl inositol 3' (PI3) kinase involved in glucose transport and peroxisome proliferator receptor gamma (PPAR γ) in L6 myotubes. The results of the present study indicate that an increase in the expressions of GLUT4, PI3 kinase in parallel with glucose uptake and PPARγ, supported the invitro glucose uptake activity of resveratrol. It is concluded that resveratrol mediates glucose transport in a PI3 kinase dependant fashion.

Keywords


Resveratrol, L6 Myotubes, Glucose Uptake, GLUT4, PPARγ, PI3 Kinase.