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Spectrophotometric Determination of Drugs Using p-Chloranilic Acid as Analytical Reagent


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1 Department of Chemistry, Nizam College, Hyderabad, 500 001, India
     

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Six drugs viz., Metoprolol tartrate, Torsemide, Diclofenac sodium, Chlorpheniramine, Loratadine and irbesartan were tested for the formation of charge transfer complexes with p-CA and the interaction formed a basis for quantitative determination of the drugs spectrophotometrically. CH3CN was found to be suitable for the analysis. The methods have been validated in terms of ICH guidelunes The complexes were found to have 1:1 composition and have stability of the order 105.

Keywords

Spectrophotometry, p-CA, Drug, Quantification, Validation.
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  • Spectrophotometric Determination of Drugs Using p-Chloranilic Acid as Analytical Reagent

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Authors

K. Damodar Reddy
Department of Chemistry, Nizam College, Hyderabad, 500 001, India
Sayaji Rao
Department of Chemistry, Nizam College, Hyderabad, 500 001, India
G. Venkateshwarlu
Department of Chemistry, Nizam College, Hyderabad, 500 001, India

Abstract


Six drugs viz., Metoprolol tartrate, Torsemide, Diclofenac sodium, Chlorpheniramine, Loratadine and irbesartan were tested for the formation of charge transfer complexes with p-CA and the interaction formed a basis for quantitative determination of the drugs spectrophotometrically. CH3CN was found to be suitable for the analysis. The methods have been validated in terms of ICH guidelunes The complexes were found to have 1:1 composition and have stability of the order 105.

Keywords


Spectrophotometry, p-CA, Drug, Quantification, Validation.