Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Multicomponent Estimation of Salmeterol Xinafoate and Fluticasone Propionate in Bulk and Capsule Dosage Form by Ultraviolet Spectroscopy


Affiliations
1 Appasaheb Birnale College of Pharmacy, Sangli-416416, Maharashtra, India
     

   Subscribe/Renew Journal


A simple, accurate, sensitive, selective, precise and robust spectrophotometric method of analysis was suggested for determination of antiasthmatic drugs; Salmeterol xinafoate and Fluticasone propionate. The estimation of drugs was based on multicomponent mode of analysis, which involves the measurement of absorbance at two wavelengths 214 nm (λmax of SX) and 246 nm (λmax of FP). Phosphate buffer (pH 7.4): Ethanol (95%) (90:10) was used as solvent. The mean results of estimation for in capsule were 99.93±0.13 %&99.92±0.19 % for Salmeterol and Fluticasone respectively of the label claim. The proposed method was found to be linear in the range of 2 - 10 μg/ml with mean recovery in the range of 99.76% to 100.54%, for both the drugs. The developed new method was validated according to ICH guidelines and found to be accurate and precise. Thus the proposed method can be successfully applied for determination of Salmeterol xinafoate and Fluticasone propionate in routine analysis work.

Keywords

Salmeterol Xinafoate, Fluticasone Propionate, UV Spectroscopy, Multicomponent Mode, Capsule Dosage Form.
Subscription Login to verify subscription
User
Notifications
Font Size


Abstract Views: 198

PDF Views: 0




  • Multicomponent Estimation of Salmeterol Xinafoate and Fluticasone Propionate in Bulk and Capsule Dosage Form by Ultraviolet Spectroscopy

Abstract Views: 198  |  PDF Views: 0

Authors

Vishal V. Shah
Appasaheb Birnale College of Pharmacy, Sangli-416416, Maharashtra, India
Smita J. Patil
Appasaheb Birnale College of Pharmacy, Sangli-416416, Maharashtra, India
Nutan D. Shah
Appasaheb Birnale College of Pharmacy, Sangli-416416, Maharashtra, India

Abstract


A simple, accurate, sensitive, selective, precise and robust spectrophotometric method of analysis was suggested for determination of antiasthmatic drugs; Salmeterol xinafoate and Fluticasone propionate. The estimation of drugs was based on multicomponent mode of analysis, which involves the measurement of absorbance at two wavelengths 214 nm (λmax of SX) and 246 nm (λmax of FP). Phosphate buffer (pH 7.4): Ethanol (95%) (90:10) was used as solvent. The mean results of estimation for in capsule were 99.93±0.13 %&99.92±0.19 % for Salmeterol and Fluticasone respectively of the label claim. The proposed method was found to be linear in the range of 2 - 10 μg/ml with mean recovery in the range of 99.76% to 100.54%, for both the drugs. The developed new method was validated according to ICH guidelines and found to be accurate and precise. Thus the proposed method can be successfully applied for determination of Salmeterol xinafoate and Fluticasone propionate in routine analysis work.

Keywords


Salmeterol Xinafoate, Fluticasone Propionate, UV Spectroscopy, Multicomponent Mode, Capsule Dosage Form.