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Synthesis and Characterization of Novel Transition Metal Complexes of 4-Methyl-7-Hydroxy 8-Formyl Coumarin and their Biological Activities


Affiliations
1 Department of Chemistry, Patkar College of Arts and Science, Goregaon (W), Mumbai 400 062, India
2 P. G. Dept of Chemistry, Govt. of Maharashtra’s Ismail Yusuf College of Arts, Science and Commerce, Jogeshwari (East), Mumbai 400 060, India
     

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Novel transition metal Cu(II), Ni(II), Co(II) and Zn(II) ions complexes of bidentate Schiff base ligand obtained from 4-Methyl 7-hydroxy 8-formyl coumarin, and Dimethylamino propylene diamine have been prepared and characterized by physical, spectral and analytical data. The synthesized Schiff base act as bidentate ligand for the complexation reaction with Cu(II), Ni(II), Co(II) and Zn(II) ions. The new compounds, possessing the general formula [M(L)2.2H2O] where [M= Cu(II), Ni(II), Co(II) and Zn(II)] show octahedral geometry. In order to evaluate the effect of metal ions upon chelation, the Schiff base and their metal complexes have been screened for antimicrobial activity. The transition metal complexes have shown enhanced antimicrobial activities as compared to Schiff base.

Keywords

Schiff Bases, 4-Methyl 7-Hydroxy 8-Formyl Coumarin, Transition Metal Complexes.
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  • Synthesis and Characterization of Novel Transition Metal Complexes of 4-Methyl-7-Hydroxy 8-Formyl Coumarin and their Biological Activities

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Authors

Vijaya Pawar
Department of Chemistry, Patkar College of Arts and Science, Goregaon (W), Mumbai 400 062, India
Sangeeta V. Chavan
Department of Chemistry, Patkar College of Arts and Science, Goregaon (W), Mumbai 400 062, India
Ramesh S. Yamgar
Department of Chemistry, Patkar College of Arts and Science, Goregaon (W), Mumbai 400 062, India
R. G. Atram
P. G. Dept of Chemistry, Govt. of Maharashtra’s Ismail Yusuf College of Arts, Science and Commerce, Jogeshwari (East), Mumbai 400 060, India
B. R. Thorat
P. G. Dept of Chemistry, Govt. of Maharashtra’s Ismail Yusuf College of Arts, Science and Commerce, Jogeshwari (East), Mumbai 400 060, India
Swati Bisht
P. G. Dept of Chemistry, Govt. of Maharashtra’s Ismail Yusuf College of Arts, Science and Commerce, Jogeshwari (East), Mumbai 400 060, India
Sudhir S. Sawant
P. G. Dept of Chemistry, Govt. of Maharashtra’s Ismail Yusuf College of Arts, Science and Commerce, Jogeshwari (East), Mumbai 400 060, India

Abstract


Novel transition metal Cu(II), Ni(II), Co(II) and Zn(II) ions complexes of bidentate Schiff base ligand obtained from 4-Methyl 7-hydroxy 8-formyl coumarin, and Dimethylamino propylene diamine have been prepared and characterized by physical, spectral and analytical data. The synthesized Schiff base act as bidentate ligand for the complexation reaction with Cu(II), Ni(II), Co(II) and Zn(II) ions. The new compounds, possessing the general formula [M(L)2.2H2O] where [M= Cu(II), Ni(II), Co(II) and Zn(II)] show octahedral geometry. In order to evaluate the effect of metal ions upon chelation, the Schiff base and their metal complexes have been screened for antimicrobial activity. The transition metal complexes have shown enhanced antimicrobial activities as compared to Schiff base.

Keywords


Schiff Bases, 4-Methyl 7-Hydroxy 8-Formyl Coumarin, Transition Metal Complexes.