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Synthesis, Spectroscopic, Thermal Characterization and Biological Activity of (E)-4-(4-Methoxybenzylideneamino)-N-(5-Methylisoxazol-3-Yl) Benzenesulfonamide and Its Copper Complexes


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1 Al-Azhar University, Cairo, Egypt
     

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A Schiff base (E)-4-(4-methoxybenzylideneamino)-N-(5-methylis-oxazol-3-yl) benzene-sulfonamide (C18H17N3O4S), and its copper complex were synthesized and the structures elucidated in the bases of elemental analysis, HNMR, UV-VIS, IR, Mass spectroscopy, magnetic susceptibility, thermal analysis and conductance measurements. The studies indicate an octahedral structure for the complexes with the (C22H27N3O10SCu ) formula. The I.R. spectra suggest that the ligand acts as a tridentate (NNO) donor. Also, the biological activity of the Schiff base and its Cu complex are biologically active.


Keywords

Sulphamethoxazole, Schiff Base, Copper Complex, Antibacterial and Antifungal Activities.
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  • Synthesis, Spectroscopic, Thermal Characterization and Biological Activity of (E)-4-(4-Methoxybenzylideneamino)-N-(5-Methylisoxazol-3-Yl) Benzenesulfonamide and Its Copper Complexes

Abstract Views: 164  |  PDF Views: 0

Authors

M. Elnawawy
Al-Azhar University, Cairo, Egypt
R. S. Farag
Al-Azhar University, Cairo, Egypt
I. A. Sbbah
Al-Azhar University, Cairo, Egypt
A. M. Abuyamine
Al-Azhar University, Cairo, Egypt

Abstract


A Schiff base (E)-4-(4-methoxybenzylideneamino)-N-(5-methylis-oxazol-3-yl) benzene-sulfonamide (C18H17N3O4S), and its copper complex were synthesized and the structures elucidated in the bases of elemental analysis, HNMR, UV-VIS, IR, Mass spectroscopy, magnetic susceptibility, thermal analysis and conductance measurements. The studies indicate an octahedral structure for the complexes with the (C22H27N3O10SCu ) formula. The I.R. spectra suggest that the ligand acts as a tridentate (NNO) donor. Also, the biological activity of the Schiff base and its Cu complex are biologically active.


Keywords


Sulphamethoxazole, Schiff Base, Copper Complex, Antibacterial and Antifungal Activities.