Asian Journal of Research in Chemistry

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CuCl2.2H2O-Catalysed One-Pot Multi-Component Synthesis of β-Acetamido Ketones


Affiliations
1 Department of Applied Chemistry, Indian School of Mines, Dhanbad-826004, Jharkhand, India
     

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One pot, four-component condensation of an aryl aldehyde, acetyl chloride, acetophenone and acetonitrile in the presence of Copper(II) chloride dihydrate is reported. Copper(II) chloride as an inexpensive, efficient, and readily available catalyst for the synthesis of β-acetamido ketones in high yields. The products obtained were clean and devoid of any undesired impurities as evident from 1H NMR, IR, and TLC analysis.

Keywords

Aryl Aldehyde, Acetyl Chloride, Acetophenone, Copper(II) Chloride, β-Acetamido Ketones.
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  • CuCl2.2H2O-Catalysed One-Pot Multi-Component Synthesis of β-Acetamido Ketones

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Authors

Rajat S. Pathak
Department of Applied Chemistry, Indian School of Mines, Dhanbad-826004, Jharkhand, India
Amiya Shekhar
Department of Applied Chemistry, Indian School of Mines, Dhanbad-826004, Jharkhand, India
Devendra D. Pathak
Department of Applied Chemistry, Indian School of Mines, Dhanbad-826004, Jharkhand, India

Abstract


One pot, four-component condensation of an aryl aldehyde, acetyl chloride, acetophenone and acetonitrile in the presence of Copper(II) chloride dihydrate is reported. Copper(II) chloride as an inexpensive, efficient, and readily available catalyst for the synthesis of β-acetamido ketones in high yields. The products obtained were clean and devoid of any undesired impurities as evident from 1H NMR, IR, and TLC analysis.

Keywords


Aryl Aldehyde, Acetyl Chloride, Acetophenone, Copper(II) Chloride, β-Acetamido Ketones.