Asian Journal of Pharmacy and Technology

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Formulation of Clotrimazole Vaginal Suppository Containing Lacto bacillus Spores


Affiliations
1 MJRP college of heath Care and Allied Sciences, MJRP university, Jaipur, India
2 Sharad Pawar College of Pharmacy, Nagpur, India
     

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Human vagina represents a dynamic ecosystem dominated by certain species of Lactobacillus. This microorganism restricts the growth of pathogens by using properties of steric exclusion and inhibitory substance production. Serious complications including bacterial vaginosis and vaginal cancer are often determined in women with reduced numbers of lactobacilli. Local application of Lactobacillus is consequently promising to keep the vagina colonized by this strain, which consequently reduces the infections. The first objective of this research was to develop a local application pharmaceutical formulation of a vaginal suppository containing lyophilized culture of Lactobacillus with anti microbial agent clotrimazole. The second objective was to establish a stable clotrimazole suppositiry alone with Lactic acid Bacillus Spores for vaginosis.

Keywords

Vaginosis,Lactic acid bacillus Spores, Clotrimazole, Formulation, Viability, Stability
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  • Formulation of Clotrimazole Vaginal Suppository Containing Lacto bacillus Spores

Abstract Views: 393  |  PDF Views: 2

Authors

S. C. Shivhare
MJRP college of heath Care and Allied Sciences, MJRP university, Jaipur, India
U. D. Shivhare
Sharad Pawar College of Pharmacy, Nagpur, India
Preeti Srivastav
MJRP college of heath Care and Allied Sciences, MJRP university, Jaipur, India
K. G. Malviya
MJRP college of heath Care and Allied Sciences, MJRP university, Jaipur, India

Abstract


Human vagina represents a dynamic ecosystem dominated by certain species of Lactobacillus. This microorganism restricts the growth of pathogens by using properties of steric exclusion and inhibitory substance production. Serious complications including bacterial vaginosis and vaginal cancer are often determined in women with reduced numbers of lactobacilli. Local application of Lactobacillus is consequently promising to keep the vagina colonized by this strain, which consequently reduces the infections. The first objective of this research was to develop a local application pharmaceutical formulation of a vaginal suppository containing lyophilized culture of Lactobacillus with anti microbial agent clotrimazole. The second objective was to establish a stable clotrimazole suppositiry alone with Lactic acid Bacillus Spores for vaginosis.

Keywords


Vaginosis,Lactic acid bacillus Spores, Clotrimazole, Formulation, Viability, Stability

References