Asian Journal of Pharmacy and Technology

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Activity of Antimalarial Compounds from Ethyl Acetate Fraction of Sunflower Leaves (Helianthus annuus L.) against Plasmodium falciparum Parasites 3D7 Strain


Affiliations
1 Department of Pharmacy, Universitas Islam Negeri Maulana Malik, Ibrahim Malang, Indonesia
2 Chemistry Department, Universitas Islam Negeri Maulana Malik Ibrahim Malang, Maulana Malik, Ibrahim Malang, Indonesia
3 Department of Pharmacognosy and Phytochemistry, Universitas Airlangga, Indonesia
     

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Antimalarial study using methanol extract and ethyl acetate fraction of sunflower leaves had been done. The study was conducted to know antimalarial activity between methanol extract and ethyl acetate fraction at Plasmodium falciparum parasites 3D7 strain. Separation of compounds was done by maceration using methanol and partition using ethyl acetate. Identification of ethyl acetate fraction was done by using UPLC-MS instrument. The results shown ethyl acetate fraction obtained the highest peak based on database were artemisinin, heliangolide, linolenic acid, linoleic acid eupalinolide C. The results of antimalarial study shown that methanol extract had IC50 22.18 mg / mL, and ethyl acetate fraction had IC50 16.68 mg / mL. Antimalarial activity between methanol extract and ethyl acetate fraction showed no significant difference.


Keywords

Sunflower leaves, Antimalarial, Plasmodium falciparum Strain 3D7, UPLC-MS.
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  • Activity of Antimalarial Compounds from Ethyl Acetate Fraction of Sunflower Leaves (Helianthus annuus L.) against Plasmodium falciparum Parasites 3D7 Strain

Abstract Views: 272  |  PDF Views: 5

Authors

Roihatul Mutiah
Department of Pharmacy, Universitas Islam Negeri Maulana Malik, Ibrahim Malang, Indonesia
Riadul Badiah
Chemistry Department, Universitas Islam Negeri Maulana Malik Ibrahim Malang, Maulana Malik, Ibrahim Malang, Indonesia
Elok Kamilah Hayati
Chemistry Department, Universitas Islam Negeri Maulana Malik Ibrahim Malang, Maulana Malik, Ibrahim Malang, Indonesia
Aty Widyawaruyanti
Department of Pharmacognosy and Phytochemistry, Universitas Airlangga, Indonesia

Abstract


Antimalarial study using methanol extract and ethyl acetate fraction of sunflower leaves had been done. The study was conducted to know antimalarial activity between methanol extract and ethyl acetate fraction at Plasmodium falciparum parasites 3D7 strain. Separation of compounds was done by maceration using methanol and partition using ethyl acetate. Identification of ethyl acetate fraction was done by using UPLC-MS instrument. The results shown ethyl acetate fraction obtained the highest peak based on database were artemisinin, heliangolide, linolenic acid, linoleic acid eupalinolide C. The results of antimalarial study shown that methanol extract had IC50 22.18 mg / mL, and ethyl acetate fraction had IC50 16.68 mg / mL. Antimalarial activity between methanol extract and ethyl acetate fraction showed no significant difference.


Keywords


Sunflower leaves, Antimalarial, Plasmodium falciparum Strain 3D7, UPLC-MS.