Asian Journal of Pharmacy and Technology

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Evaluation of Antiulcer Activity of Couroupita guianensis Aubl Leaves


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1 Department of Pharmacognosy, Anurag Pharmacy College, Ananthagiri (V), Kodad(M), Nalgonda (Dt), Andhra Pradesh, 508 206, India
     

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The antiulcer activity of ethanolic extract of Couroupita guianensis leaves (EECG) was investigated in pylorus ligation and ethanol induced ulcer models in experimental rats. In both models the common parameter determined was ulcer index. Ethanolic extract of Couroupita guianensis at a dose of 150 and 300mg/kg produced significant inhibition of the gastric lesions induced by pylorus ligation induced ulcer and ethanol induced gastric ulcer. The extract (150mg/kg and 300mg/kg) showed significant (p<0.05) reduction in gastric volume, free acidity and ulcer index as compared to control. This present study indicates that EECG have potential anti-ulcer activity in both models. These results may further suggest that the extract was found to possess antiulcerogenic as well as ulcer healing properties, which might be due to its antisecretory activity.

Keywords

Ethanolic Extract, Couroupita guianensis, Pylorus Ligation, Ethanol Induced Ulcer Model, Ulcer Index, Ranitidine.
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  • Evaluation of Antiulcer Activity of Couroupita guianensis Aubl Leaves

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Authors

A. Elumalai
Department of Pharmacognosy, Anurag Pharmacy College, Ananthagiri (V), Kodad(M), Nalgonda (Dt), Andhra Pradesh, 508 206, India
V. Naresh
Department of Pharmacognosy, Anurag Pharmacy College, Ananthagiri (V), Kodad(M), Nalgonda (Dt), Andhra Pradesh, 508 206, India
M. Chinna Eswaraiah
Department of Pharmacognosy, Anurag Pharmacy College, Ananthagiri (V), Kodad(M), Nalgonda (Dt), Andhra Pradesh, 508 206, India
P. Narendar
Department of Pharmacognosy, Anurag Pharmacy College, Ananthagiri (V), Kodad(M), Nalgonda (Dt), Andhra Pradesh, 508 206, India
Raj Kumar
Department of Pharmacognosy, Anurag Pharmacy College, Ananthagiri (V), Kodad(M), Nalgonda (Dt), Andhra Pradesh, 508 206, India

Abstract


The antiulcer activity of ethanolic extract of Couroupita guianensis leaves (EECG) was investigated in pylorus ligation and ethanol induced ulcer models in experimental rats. In both models the common parameter determined was ulcer index. Ethanolic extract of Couroupita guianensis at a dose of 150 and 300mg/kg produced significant inhibition of the gastric lesions induced by pylorus ligation induced ulcer and ethanol induced gastric ulcer. The extract (150mg/kg and 300mg/kg) showed significant (p<0.05) reduction in gastric volume, free acidity and ulcer index as compared to control. This present study indicates that EECG have potential anti-ulcer activity in both models. These results may further suggest that the extract was found to possess antiulcerogenic as well as ulcer healing properties, which might be due to its antisecretory activity.

Keywords


Ethanolic Extract, Couroupita guianensis, Pylorus Ligation, Ethanol Induced Ulcer Model, Ulcer Index, Ranitidine.