Asian Journal of Pharmacy and Technology

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In-Vitro Anti-Inflammatory Activity of Fractions of Ailanthus excelsa Roxb. by HRBC Membrane Stabilization


Affiliations
1 Department of Pharmacognosy, Atmiya Institute of Pharmacy, Yogidham Campus, Kalawad Road, Rajkot, Gujarat, India
2 Department of Pharmacognosy, Atmiya Institute of Pharmacy, Yogidham Campus, Kalawad Road, Rajkot, Gujarat, India
     

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Present study deals with membrane stabilizing activity of petroleum ether, ethyl acetate and methanol fractions of leaves of Ailanthus excelsa. The phytochemical screening of the leaves of Ailanthus excelsa revealed the presence of alkaloids, sterols, saponins, flavonoids, phenolic compounds, carbohydrates and proteins. The inhibition of heat induced HRBC membrane lysis was taken as a measure of the anti inflammatory activity. The methanol fraction showed the most significant membrane stabilizing action on HRBC membrane as compare to other fractions. The maximum membrane stabilization of methanol fraction of A. excelsa was found to be 91.13% at a dose of 1000 μg/ml.

Keywords

Anti Inflammatory, Ailanthus excelsa, HRBC Membrane Stabilization.
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  • In-Vitro Anti-Inflammatory Activity of Fractions of Ailanthus excelsa Roxb. by HRBC Membrane Stabilization

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Authors

Prakash Siju
Department of Pharmacognosy, Atmiya Institute of Pharmacy, Yogidham Campus, Kalawad Road, Rajkot, Gujarat, India
Rohit Ghetia
Department of Pharmacognosy, Atmiya Institute of Pharmacy, Yogidham Campus, Kalawad Road, Rajkot, Gujarat, India
Bhavin Vadher
Department of Pharmacognosy, Atmiya Institute of Pharmacy, Yogidham Campus, Kalawad Road, Rajkot, Gujarat, India
Mital N. Manvar
Department of Pharmacognosy, Atmiya Institute of Pharmacy, Yogidham Campus, Kalawad Road, Rajkot, Gujarat, India

Abstract


Present study deals with membrane stabilizing activity of petroleum ether, ethyl acetate and methanol fractions of leaves of Ailanthus excelsa. The phytochemical screening of the leaves of Ailanthus excelsa revealed the presence of alkaloids, sterols, saponins, flavonoids, phenolic compounds, carbohydrates and proteins. The inhibition of heat induced HRBC membrane lysis was taken as a measure of the anti inflammatory activity. The methanol fraction showed the most significant membrane stabilizing action on HRBC membrane as compare to other fractions. The maximum membrane stabilization of methanol fraction of A. excelsa was found to be 91.13% at a dose of 1000 μg/ml.

Keywords


Anti Inflammatory, Ailanthus excelsa, HRBC Membrane Stabilization.