Asian Journal of Pharmaceutical Research

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Recent Advance in Gastroretantive Drug Delivery System (GRDDS)


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1 Institute Name, Shri Sant Gajanan Mharaj College of Pharmacy Buldhana Maharastra 443001, India
     

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The drug delivery system is most important and preferable drug delivery system. This route has high patient acceptability, primarily due to easy of administration. Effective oral drug delivery depends upon the factors such as gastric emptying process, the gastrointestinal transit time of the dosage form drug release from the dosage form, and site of absorption of drug. In recent years, scientific and technological advancements have been made in the research and development of gastro retentive drug delivery systems. Hence forth a wide spectrum of dosage forms has been developed for the drugs which have narrow absorption window, unstable at intestinal pH, are soluble in acidic pH, and have a site of action specific to stomach. The purpose of writing this review was to investigate, compile and present the recent as well as past literature in a more concise way with a special focus on approaches that are currently utilized in the prolongation of gastric residence time. These include floating system, swelling and expanding system, bio/mucoadhesive system, high-density system, and other delayed gastric emptying devices. The present review addresses briefly the classification, formulation consideration for Gastroretantive drug delivery system (GRDDS), factors controlling gastric retention, merits, demerits, and applications of gastro retentive drug delivery systems.


Keywords

Gastro retentive drug delivery system, floating system, swelling, expanding system, bio/mucoadhesive system, high-density system, H Pylori infection and its Application
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  • Recent Advance in Gastroretantive Drug Delivery System (GRDDS)

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Authors

Ashwini A Zanke
Institute Name, Shri Sant Gajanan Mharaj College of Pharmacy Buldhana Maharastra 443001, India
Hemant H Gangurde
Institute Name, Shri Sant Gajanan Mharaj College of Pharmacy Buldhana Maharastra 443001, India
Ananta B Ghonge
Institute Name, Shri Sant Gajanan Mharaj College of Pharmacy Buldhana Maharastra 443001, India
Praful S. Chavan
Institute Name, Shri Sant Gajanan Mharaj College of Pharmacy Buldhana Maharastra 443001, India

Abstract


The drug delivery system is most important and preferable drug delivery system. This route has high patient acceptability, primarily due to easy of administration. Effective oral drug delivery depends upon the factors such as gastric emptying process, the gastrointestinal transit time of the dosage form drug release from the dosage form, and site of absorption of drug. In recent years, scientific and technological advancements have been made in the research and development of gastro retentive drug delivery systems. Hence forth a wide spectrum of dosage forms has been developed for the drugs which have narrow absorption window, unstable at intestinal pH, are soluble in acidic pH, and have a site of action specific to stomach. The purpose of writing this review was to investigate, compile and present the recent as well as past literature in a more concise way with a special focus on approaches that are currently utilized in the prolongation of gastric residence time. These include floating system, swelling and expanding system, bio/mucoadhesive system, high-density system, and other delayed gastric emptying devices. The present review addresses briefly the classification, formulation consideration for Gastroretantive drug delivery system (GRDDS), factors controlling gastric retention, merits, demerits, and applications of gastro retentive drug delivery systems.


Keywords


Gastro retentive drug delivery system, floating system, swelling, expanding system, bio/mucoadhesive system, high-density system, H Pylori infection and its Application

References