Asian Journal of Pharmaceutical Research

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Evaluation of Anti-bacterial and Anti-inflammatory Activities of Ethanolic Extract of Hibiscus hirtus Linn. Leaves


Affiliations
1 Department of Chemistry, A.K.R.G. College of Pharmacy, Nallajerla, Andhra Pradesh, India
2 Dept. of Pharmacology, Brilliant Group of Institutions, Abdullapaur, R.R. Dist., Hyderabad, Telangana, India
3 Department of Analysis, A.K.R.G. College of Pharmacy, Nallajerla, Andhra Pradesh, India
4 Vijaya Teja Degree College, Addanki, Andhra Pradesh, India
     

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The current investigation is started to find the antibacterial and anti-inflammatory activities of the sub shrub Hibiscus hirtus L. The leaves of this conventional shrub were found to possess' different activities which incorporate antibacterial and hostile to helminthic effects. Thus we made an endeavor to perform extraction utilizing ethanol as solvent and soxhlation as a strategy for extraction. The leaves were priorly researched for their pharmacognostic, phytochemical and physical parameters. The antibacterial action of the ethanolic leaf extract was conveyed at various concentrations on strains of gram positive and gram-negative bacteria, for example, Staphylococcus aureus and Escherechia coli individually by utilizing cup and plate technique. The outcomes were outfitted as the zone of inbition acquired around every grouping of the concentrate and were compared with those of standard antibiotic utilized in the analysis, amoxycillin. Anti-inflammatory activity of Hibiscus hirtus L was studied and compared with standard drug, ibuprofen. Ethanollic concentrate of leaves (2.5- 15 mg/ml) and ibuprofen (2.5-15 mg/ml) were utilized to measure the paw edema by plethysmometer and compared with control groups. Hibiscus hirtus L showed critical decrease of paw edema in the chosen model of inflammation for example formalin prompted chronic model of inflammation. Ethanollic concentrate of the plant leaves showed anti- microbial and anti-inflammatory impacts.


Keywords

Hibiscus hirtus L, Anti-inflammatory, Antimicrobial activity, Extraction
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  • Evaluation of Anti-bacterial and Anti-inflammatory Activities of Ethanolic Extract of Hibiscus hirtus Linn. Leaves

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Authors

Nalla Priyanka
Department of Chemistry, A.K.R.G. College of Pharmacy, Nallajerla, Andhra Pradesh, India
P. Brahmeswari
Dept. of Pharmacology, Brilliant Group of Institutions, Abdullapaur, R.R. Dist., Hyderabad, Telangana, India
G. Raveendra Babu
Department of Analysis, A.K.R.G. College of Pharmacy, Nallajerla, Andhra Pradesh, India
M. Sowjanya
Vijaya Teja Degree College, Addanki, Andhra Pradesh, India
M. Ramayyappa
Department of Analysis, A.K.R.G. College of Pharmacy, Nallajerla, Andhra Pradesh, India

Abstract


The current investigation is started to find the antibacterial and anti-inflammatory activities of the sub shrub Hibiscus hirtus L. The leaves of this conventional shrub were found to possess' different activities which incorporate antibacterial and hostile to helminthic effects. Thus we made an endeavor to perform extraction utilizing ethanol as solvent and soxhlation as a strategy for extraction. The leaves were priorly researched for their pharmacognostic, phytochemical and physical parameters. The antibacterial action of the ethanolic leaf extract was conveyed at various concentrations on strains of gram positive and gram-negative bacteria, for example, Staphylococcus aureus and Escherechia coli individually by utilizing cup and plate technique. The outcomes were outfitted as the zone of inbition acquired around every grouping of the concentrate and were compared with those of standard antibiotic utilized in the analysis, amoxycillin. Anti-inflammatory activity of Hibiscus hirtus L was studied and compared with standard drug, ibuprofen. Ethanollic concentrate of leaves (2.5- 15 mg/ml) and ibuprofen (2.5-15 mg/ml) were utilized to measure the paw edema by plethysmometer and compared with control groups. Hibiscus hirtus L showed critical decrease of paw edema in the chosen model of inflammation for example formalin prompted chronic model of inflammation. Ethanollic concentrate of the plant leaves showed anti- microbial and anti-inflammatory impacts.


Keywords


Hibiscus hirtus L, Anti-inflammatory, Antimicrobial activity, Extraction

References