Central Nervous System Depressant Activity of Aqueous Extract of Leaves of Azadirachta indica Linn in Mice

Aim of the study to investigate the effects of Acetone extract of Azadirachta indica on central nervous system and possibility to use it as folk medicine. The Acetone extract of Azadirachta indica was soxhlat extracted with Acetone and concentrated. The effect of Acetone extract on CNS was studied by using analgesic activity and sedative-hypnotic activity. Preliminary phytochemical evaluation of extract was also carried out. The extract (100mg and 200mg/kg, i.p) showed significant (p<0.001) potentiation of reaction time to thermal stimulus. It also showed significant (p<0.01). Potentiation o phenobarbitone induced sleeping time to control.