QSAR Study and Synthesis of Some New 2, 5-Disubstituted 1, 3, 4-Oxadiazole Derivatives as Anti-Microbial and Anti-Inflammatory Agents

The synthesis, structure and biological activity of Oxadiazole derivatives have long been the focus of research interests in the field of Medicinal Chemistry. A number of Oxadiazole derivatives have been reported to possess interesting biological activities such as Antimicrobial, Anti-inflammatory and Antifungal activities etc. All synthesized compound were characterized by IR, H¬1-NMR and elemental Analysis. All the compounds were evaluated for Antibacterial and Anti-inflammatory at the concentration of 200 μcg/mL by using cup-plate agar diffusion method. The activity was carried out on different micro-organisms (E.coli, S. aureus, A.niger, C. albicans) measured in terms of zone of inhibition and compared the standard drug Ciprofloxacin and Amphotericin B for antimicrobial activity. All the newly synthesized derivatives were screened for Anti-inflammatory activity by an in-vitro method of Inhibition of protein denaturation using Zaltoprofen as a standard.