Functional Annotation of Histone Proteins in Human

Proteins are very much useful components and their functional annotation is also very useful as well. The function of protein is the measure of the expression of that particular protein. By knowing the function of one protein it can be found out the function of that protein also which has conserved region of the above protein whose function is known. PANDORA is a web based tool to aid biologist in interpretation of protein sets without the need of examining each individual protein. The general approach that PANDORA uses is based on annotation. In PANDORA, annotations are treated as binary properties that can be assigned to proteins. In relation with histone protein family we find out not only functional annotation but the evolutionary relationship with the family members of histone protein. PANDORA gives results for histone protein family. It provides more white the nodes which mean the sensitivity is higher, that are close to 1, reflect the result that fraction of the proteins with annotation. Specificity provides the data that is always more than 0, that gives the result that fraction of protein set has annotation.