Heat Shock Proteins (HSP)-As Vaccines Vehicle

Since the report on the heat-induced appearance of chromosomal puffings in salivary gland tissue of Drosophila busckii in 1962, a new research domain has been intensively explored. This research resulted in the discovery of large number of related proteins and their physiological role in many prokaryotic and eukaryotic organisms, tissues and individual cells and at the level of sub-cellular structures. These proteins were originally called “heat shock proteins”, because they were discovered in salivary glands and other tissues of Drosophila melanogaster recovering from a so-called transient sublethal heat shock, during which body temperature was increased nearly 5°C above normal body temperature care.