Activity of Ketoconazole Coated Gold Nanoparticles Against Dandruff Causing Fungi

We investigated the antifungal property of gold Nanoparticles coated with ketoconazole against the dandruff causing organism-Malassezia pachydermatis in comparison with pure ketoconazole by disc diffusion method. The diameter of the inhibition zone is greater for gold Nanoparticles coated with ketoconazole than for pure ketoconazole. This shows that gold Nanoparticles enhances the bioactivity of ketoconazole. Zone of inhibition increased with increase in concentration of gold Nanoparticles (0.1 mM<0.2 mM<0.3 mM). We conclude that ketoconazole coated gold Nanoparticles prevent the growth of the dandruff causing organism. The inhibitory power is greater than the pure drug. Thus, gold Nanoparticles can be incorporated along with ketoconazole and formulated into an effective antidandruff shampoo.