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Venkatnarayanan, R.
- A Validated Reversed Phase HPLC-Method for the Determination of Aceclofenac and Tizanidine in Tablets
Abstract Views :311 |
PDF Views:159
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Asian Journal of Pharmaceutical Research and Health Care, Vol 2, No 1 (2010), Pagination: 84-94Abstract
A new simple, accurate, precise and reproducible Reverse Phase-High Performance Liquid Chromatographic method has been developed for the simultaneous estimation of Aceclofenac and Tizanidine in tablet dosage forms using C18 column (Ineretsil, 250 x 4.6 mm, 5 μm) in isocratic mode. The mobile phase consisted of acetonitrile, methanol and 20 mM phosphate buffer adjusted to pH 3.5 in ratio of (40:30:30 v/v) with Ultraviolet-Visible detection at 230 nm. The method was linear over the concentration range for aceclofenac120-280 μg/ml and for tizanidine 2-40 μg/ml. The recoveries of Tizanidine and Aceclofenac were found to be in the range of 99.45-100.61% and 99.56-101.32% respectively. The validation of method was carried out using International Conference on Harmonization-guidelines. The described High Performance Liquid Chromatographic method was successfully employed for the analysis of pharmaceutical formulations containing combined dosage form.Keywords
Simultaneous Estimation, RP - HPLC, Aceclofenac, Tizanidine, ICH Guidelines.- Derivatized HPTLC Method for Simultaneous Estimation of Glucosamine and Ibuprofen in Tablets
Abstract Views :228 |
PDF Views:151
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Asian Journal of Pharmaceutical Research and Health Care, Vol 2, No 2 (2010), Pagination: 156-162Abstract
A selective, precise and derivatized HPTLC method has been developed for the simultaneous estimation of Glucosamine and Ibuprofen in tablet formulation. In this method standard and sample solutions of Glucosamine and Ibuprofen were applied on pre-coated silica gel 60F254 TLC plate, and developed using Propanol-Ethyl acetate-Ammonia-Water (4: 3: 2: 1 v/v), as mobile phase and derivatized using Iodine vapor. The drugs on the plate were scanned at 254 nm. The dynamic linearity range was 5-25 μg/spot for Glucosamine and 2-10 μg/spot for Ibuprofen. The method was validated for precision, recovery and reproducibility.Keywords
Simultaneous Estimation, HPTLC, Glucosamine and Ibuprofen.- Evaluation of Standards of Some Selected Cosmetic Preparations
Abstract Views :191 |
PDF Views:136